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1. (WO2016063296) POLYPRENYLATED PHLOROGLUCINOL COMPOUNDS AS POTENT P-GLYCOPROTEIN INDUCERS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/063296 International Application No.: PCT/IN2015/050069
Publication Date: 28.04.2016 International Filing Date: 20.07.2015
IPC:
C07C 205/34 (2006.01) ,C07C 49/733 (2006.01) ,C07C 53/122 (2006.01) ,C07C 59/90 (2006.01) ,A61K 31/122 (2006.01) ,A61P 25/28 (2006.01) ,C07D 311/96 (2006.01)
Applicants: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH[IN/IN]; Anusandhan Bhawan, Rafi Marg, New Delhi 110001, IN
Inventors: BHARATE, Sandip; IN
KUMAR, Ajay; IN
BHARATE, Jaideep; IN
JOSHI, Prashant; IN
WANI, Abubakar; IN
MUDUDUDDLA, Ramesh; IN
SHARMA, Rohit; IN
VISHWAKARMA, Ram; IN
Agent: SRIHARI, Saragur, Kasturirangan; IN
CHADHA, Namrata; IN
TIWARI,, Amrish; IN
CHOPRA, Priyanka; IN
KUMARI, Jyoti; IN
ARORA, Kavita; IN
TIKU,, Deepa, Kachroo; IN
Priority Data:
3004/DEL/201421.10.2014IN
Title (EN) POLYPRENYLATED PHLOROGLUCINOL COMPOUNDS AS POTENT P-GLYCOPROTEIN INDUCERS
(FR) COMPOSÉS PHLOROGLUCINOL POLYPRÉNYLÉ COMME INDUCTEURS PUISSANTS DE LA GLYCOPROTÉINE P
Abstract: front page image
(EN) The present invention relates to the polyprenylated phloroglucinol compounds of formulae I and II. The present invention also provides synthesis and p-glycoprotein induction activity of the alkyl- and acyl- polyprenylated phloroglucinol compounds. Further, use of the compounds as p-glycoprotein inducers and methods of treatment of Alzheimer's disease using compounds of the invention are also provided.
(FR) La présente invention concerne les composés phloroglucinol polyprénylé des formules I et II. La présente invention concerne également la synthèse et l'activité d'induction de la glycoprotéine p des composés alkyle-phloroglucinol et acyle-phloroglucinol polyprénylés. Elle concerne en outre l'utilisation de ces composés comme inducteurs de la glycoprotéine p et des méthodes de traitement de la maladie d'Alzheimer à l'aide de composés selon l'invention.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)