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1. (WO2016063225) MONOPLASMID POLYPLEX PREPARATION

Pub. No.:    WO/2016/063225    International Application No.:    PCT/IB2015/058112
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Thu Oct 22 01:59:59 CEST 2015
IPC: A61K 47/48
C08L 79/02
C12N 15/88
Applicants: UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
Inventors: GUEGAN, Philippe
MATHE, Jérôme
MIDOUX, Patrick
TARNAUD, Elodie
Title: MONOPLASMID POLYPLEX PREPARATION
Abstract:
The invention relates to a method of preparing complexes of charged polymer(s) and a single molecule of interest having an opposite charge, in particular polyplexes comprising a cationic polymer and a single nucleic acid molecule, in particular a plasmid. The invention also relates to the complexes obtained by the method and their use for in vitro, ex vivo and in vivo transfection of charged molecules of interest, in particular therapeutic molecules, such as in particular nucleic acids.