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1. (WO2016063075) BIOMARKER AND THERAPY INTERVENTION FOR MALIGNANCY RISK PATIENTS

Pub. No.:    WO/2016/063075    International Application No.:    PCT/GB2015/053176
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Sat Oct 24 01:59:59 CEST 2015
IPC: G01N 33/574
Applicants: OXFORD UNIVERSITY INNOVATION LIMITED
Inventors: HARDEN, Paul Neil
WOOD, Kathyrn Jayne
BOTTOMLEY, Matthew James
Title: BIOMARKER AND THERAPY INTERVENTION FOR MALIGNANCY RISK PATIENTS
Abstract:
The invention relates to a method of determining an increased risk of cancer in an immunosuppressed patient, the method comprising: (a) determining the percentage of CD8+CD57+ T-cells in a population of CD8+ T-cells in a sample from the patient; wherein a percentage of 40% or greater of CD8+CD57+ T-cells is indicative of an increased risk of cancer; and/or (b) determining the percentage of CD4+CD57+ T-cells in a population of CD4+ T-cells in a sample from the patient; wherein a percentage of 10% or greater of CD4+CD57+ T-cells is indicative of an increased risk of cancer.