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Machine translation
1. (WO2016063026) SELECTIVE NAV PROTEIN BINDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/063026    International Application No.:    PCT/GB2015/053110
Publication Date: 28.04.2016 International Filing Date: 20.10.2015
IPC:
C07K 16/28 (2006.01)
Applicants: KYMAB LTD [GB/GB]; Bennet Building (B930) Babraham Research Campus Cambridge CB22 3AT (GB)
Inventors: CLARK, Nigel; (GB).
LEE, E-Chiang; (GB)
Agent: SMITH, Stephen Edward; (GB)
Priority Data:
1418713.2 21.10.2014 GB
Title (EN) SELECTIVE NAV PROTEIN BINDERS
(FR) SÉQUENCES DE LIAISON SÉLECTIVES POUR LA PROTÉINE NAV
Abstract: front page image
(EN)The invention provides antibodies and fragments thereof which bind to human Nav1.7, as well as nucleic acids, vectors, host cells and hybridomas for making the same. Further provided are pharmaceutical compositions for use in treating, preventing and/or reducing the risk of a NAV1.7-mediated conditions or diseases, such as pain, inflammation, and metabolic/chronic diseases. The invention additionally provides methods of generating an antibody against a NAV protein of interest.
(FR)L'invention concerne des anticorps et des fragments de ceux-ci qui se lient à la protéine Nav1.7 humaine, ainsi que des acides nucléiques, des vecteurs, des cellules hôtes et des hybridomes pouvant servir à leur fabrication. L'invention concerne également des compositions pharmaceutiques utilisables dans le traitement, la prévention et/ou la réduction du risque d'apparition d'une maladie ou d'une affection à médiation par la protéine Nav1.7, telle que la douleur, l'inflammation et les maladies métaboliques/chroniques. L'invention concerne, en outre, des procédés de génération d'un anticorps dirigé contre une protéine Nav d'intérêt.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)