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1. (WO2016062891) ASSESSMENT OF TGF-β CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION

Pub. No.:    WO/2016/062891    International Application No.:    PCT/EP2015/074700
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Tue Oct 27 00:59:59 CET 2015
IPC: G06F 19/18
C12Q 1/68
Applicants: KONINKLIJKE PHILIPS N.V.
Inventors: VAN OOIJEN, Hendrik Jan
VAN DE STOLPE, Anja
VAN STRIJP, Dianne Arnoldina Margaretha Wilhelmina
Title: ASSESSMENT OF TGF-β CELLULAR SIGNALING PATHWAY ACTIVITY USING MATHEMATICAL MODELLING OF TARGET GENE EXPRESSION
Abstract:
The present invention relates to a computer-implemented method for inferring activity of a TGF-β cellular signaling pathway in a subject based on expression levels of three or more target genes of the TGF-β cellular signaling pathway measured in a sample of the subject. The present invention further relates to an apparatus, to a non-transitory storage medium, and to a computer program for inferring activity of a TGF-β cellular signaling pathway in a subject. The present invention further relates to a kit for measuring expression levels of three or more target genes of the TGF-β cellular signaling pathway in a sample of a subject, to a kit for inferring activity of a TGF-β cellular signaling pathway in a subject, and to the use of such kits in performing the method.