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|1. (WO2016062234) OCTAPEPTIDE MODIFIED DEXAMETHASONE, AND PREPARATION, NANOSTRUCTURE AND USE THEREOF|
|Applicants:||BEIJING YISHENG CARE MEDICAL TECHNOLOGY CO., LTD.
|Title:||OCTAPEPTIDE MODIFIED DEXAMETHASONE, AND PREPARATION, NANOSTRUCTURE AND USE THEREOF|
Disclosed in the present invention is an octapeptide of the formula Lys(AA-Asp-Gly-Arg)-Glu-Asp-Gly-modified dexamethasone, and AA in the octapeptide is L-Val or L-Phe. Also disclosed are the preparation method, nanostructure and use thereof. The octapeptide modified dexamethasone has an inhibitory effect on mouse retroauricular cardiac transplantation immunological rejection reactions, and has an inhibitory effect on inflammation caused by xylene.