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1. (WO2016062234) OCTAPEPTIDE MODIFIED DEXAMETHASONE, AND PREPARATION, NANOSTRUCTURE AND USE THEREOF

Pub. No.:    WO/2016/062234    International Application No.:    PCT/CN2015/092254
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Wed Oct 21 01:59:59 CEST 2015
IPC: C07K 7/06
C07K 1/06
C07K 1/02
B82Y 30/00
A61K 38/08
A61P 37/06
A61P 29/00
Applicants: BEIJING YISHENG CARE MEDICAL TECHNOLOGY CO., LTD.
北京益生康华医药技术有限公司
Inventors: PENG, Shiqi
彭师奇
ZHAO, Ming
赵明
WANG, Yuji
王玉记
WU, Jianhui
吴建辉
YU, Hualong
于化龙
Title: OCTAPEPTIDE MODIFIED DEXAMETHASONE, AND PREPARATION, NANOSTRUCTURE AND USE THEREOF
Abstract:
Disclosed in the present invention is an octapeptide of the formula Lys(AA-Asp-Gly-Arg)-Glu-Asp-Gly-modified dexamethasone, and AA in the octapeptide is L-Val or L-Phe. Also disclosed are the preparation method, nanostructure and use thereof. The octapeptide modified dexamethasone has an inhibitory effect on mouse retroauricular cardiac transplantation immunological rejection reactions, and has an inhibitory effect on inflammation caused by xylene.