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1. (WO2016061874) METHOD FOR PREPARING TETRODOTOXIN

Pub. No.:    WO/2016/061874    International Application No.:    PCT/CN2014/092918
Publication Date: Fri Apr 29 01:59:59 CEST 2016 International Filing Date: Thu Dec 04 00:59:59 CET 2014
IPC: C07D 491/22
Applicants: CHUNG, Winston
钟馨稼
LIU, Yandong
刘延东
Inventors: CHUNG, Winston
钟馨稼
LIU, Yandong
刘延东
Title: METHOD FOR PREPARING TETRODOTOXIN
Abstract:
Provided is a method for preparing tetrodotoxin, particularly comprising the following steps: soaking; sedimentation; flocculation; ion-exchange; low-pressure column chromatography; efficient liquid chromatography column; and crystallization. The above steps employed by the present invention are closely related, better separate tetrodotoxin from 4-epitetrodotoxin, and greatly increase a yield rate of tetrodotoxin, and the purity of the prepared tetrodotoxin is greater than 99%.