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1. (WO2016061561) FORMULATIONS HAVING ANTI-INFLAMMATORY ACTIVITY AND ANTIMICROBIAL ACTIVITY AGAINST GRAM-POSITIVE BACTERIA
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/061561 International Application No.: PCT/US2015/056111
Publication Date: 21.04.2016 International Filing Date: 16.10.2015
IPC:
A61K 9/127 (2006.01) ,C07F 9/10 (2006.01) ,C12P 7/64 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9
Medicinal preparations characterised by special physical form
10
Dispersions; Emulsions
127
Liposomes
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
F
ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
9
Compounds containing elements of the 5th Group of the Periodic System
02
Phosphorus compounds
06
without P-C bonds
08
Esters of oxyacids of phosphorus
09
Esters of phosphoric acids
10
Phosphatides, e.g. lecithin
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
64
Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
Applicants:
NATUREZA, INC. [US/US]; 51 Monarch Drive, Suite B Denison, TX 75020-0455, US
Inventors:
JAMES-MEYER, Lynn, S.; US
COLES, Gerald, C.; GB
Agent:
VANDER MOLEN, Monique, A.; US
Priority Data:
62/064,57416.10.2014US
Title (EN) FORMULATIONS HAVING ANTI-INFLAMMATORY ACTIVITY AND ANTIMICROBIAL ACTIVITY AGAINST GRAM-POSITIVE BACTERIA
(FR) FORMULATIONS AYANT UNE ACTIVITÉ ANTI-INFLAMMATOIRE ET UNE ACTIVITÉ ANTIMICROBIENNE CONTRE LES BACTÉRIES GRAM POSITIF
Abstract:
(EN) Novel active compositions having antimicrobial and anti-inflammatory activity are described, the activity provided by an active component prepared in a suspension, the active component being at least a single chain fatty acid having a carbon length of 12, or between 12 and no more than 18. The fatty acid may be esterified and/or ethylated or methylated. As an antimicrobial the active component has activity against one or more microorganisms including Staphylococcus spp., Streptococcus spp., Mycobacterium spp., Clostridium spp., and Candida spp., with an MIC as low as 0.0018 μg/ml. As an anti-inflammatory, it is at least as or is more effective than cyclosporine in preventing T-cell proliferation in response to a trigger, such as stimulation by the one or more microorganisms. The active component is more active when combined with a phospholipid (e.g., lecithin, phosphatidylcholine) and caused to form liposomal nanoparticles. It is also more active when caused to form coated liposomal nanoparticles. Compositions with said active components may be provided internally and/or topically on a surface or on skin.
(FR) La présente invention concerne des nouvelles compositions actives ayant une activité antimicrobienne et anti-inflammatoire, l’activité étant produite par un composant actif préparé dans une suspension, le composant actif étant au moins un acide gras monocaténaire ayant une longueur de carbone de 12, ou comprise entre 12 et pas plus de 18. L’acide gras peut être estérifié et/ou éthylé ou méthylé. En tant qu’antimicrobien, le composant actif a une activité contre un ou plusieurs micro-organismes dont Staphylococcus spp., Streptococcus spp., Mycobacterium spp., Clostridium spp. et Candida spp., avec une CIM aussi faible que 0,0018 μg/ml. En tant qu’anti-inflammatoire, il est au moins aussi efficace ou plus efficace que la cyclosporine dans la prévention de la prolifération de lymphocytes T en réponse à un activateur, tel qu’une stimulation par les un ou plusieurs micro-organismes. Le composant actif est plus actif lorsqu’il est combiné avec un phospholipide (par exemple, la lécithine, la phosphatidylcholine) et amené à former des nanoparticules liposomales. Il est également plus actif lorsqu’il est amené à former des nanoparticules liposomales revêtues. Les compositions avec lesdits composants actifs peuvent être disposées de façon interne et/ou topique sur une surface ou sur la peau.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)