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1. (WO2016061495) ATAVARSITIC SYSTEMS AND METHODS FOR BIOMARKER DISCOVERY

Pub. No.:    WO/2016/061495    International Application No.:    PCT/US2015/056001
Publication Date: Fri Apr 22 01:59:59 CEST 2016 International Filing Date: Sat Oct 17 01:59:59 CEST 2015
IPC: A01K 67/027
G01N 33/15
C12N 5/09
Applicants: PREDICTIVE THERAPEUTICS LTD.
Inventors: NATHAN, Asher
Title: ATAVARSITIC SYSTEMS AND METHODS FOR BIOMARKER DISCOVERY
Abstract:
The present disclosure provides methods of identifying and validating biomarkers that are predictive of drug efficacy in a patient. The disclosed methods use avatars (e.g. animal or in vitro models) to identify biomarkers associated with a particular treatment status (e.g. responder or non-responder to drug). These biomarkers are then validated by using previously obtained clinic data and clinical samples from patients who were previously treated with the drug The biomarkers can be used to identify other patient samples which are predicted to respond to given treatments, and the presence or absence of the biomarker can guide patient treatment.