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1. (WO2016061374) METHODS AND COMPOSITIONS FOR GENERATING OR MAINTAINING PLURIPOTENT CELLS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/061374    International Application No.:    PCT/US2015/055776
Publication Date: 21.04.2016 International Filing Date: 15.10.2015
IPC:
C12N 5/074 (2010.01), C12N 5/00 (2006.01)
Applicants: REGENERON PHARMACEUTICALS, INC. [US/US]; 777 Old Saw Mill River Road Tarrytown, New York 10591-6706 (US)
Inventors: KUNO, Junko; (US).
AUERBACH, Wojtek; (US).
VALENZUELA, David M.; (US)
Agent: SCHILLING, Stephen H.; (US)
Priority Data:
62/064,384 15.10.2014 US
Title (EN) METHODS AND COMPOSITIONS FOR GENERATING OR MAINTAINING PLURIPOTENT CELLS
(FR) MÉTHODES ET COMPOSITIONS DE PRODUCTION OU DE CONSERVATION DE CELLULES PLURIPOTENTES
Abstract: front page image
(EN)Methods and compositions are provided for generating or maintaining human iPS cells in culture. Methods include the use of a low osmolality medium to make human iPS cells, or use of a low osmolality medium to maintain human iPS cells. Methods for making targeted genetic modification to human iPS cells cultured in low osmolality medium are also included. Compositions include human iPS cells cultured and maintained using the low osmolality medium defined herein.
(FR)L'invention concerne des méthodes et des compositions permettant de produire ou de conserver des cellules iPS humaines en culture. Les méthodes consistent à utiliser un milieu de faible osmolalité pour préparer les cellules iPS humaines, ou à utiliser un milieu de faible osmolalité pour conserver les cellules iPS humaines. L'invention concerne également des méthodes de préparation d'une modification génétique ciblée dans les cellules iPS humaines cultivées dans le milieu de faible osmolalité. Les compositions comprennent des cellules iPS humaines cultivées et conservées en faisant appel au milieu de faible osmolalité, défini dans la description.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)