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1. (WO2016061263) ANTISENSE COMPOUNDS AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/061263    International Application No.:    PCT/US2015/055582
Publication Date: 21.04.2016 International Filing Date: 14.10.2015
IPC:
G01N 33/68 (2006.01)
Applicants: IONIS PHARMACEUTICALS, INC. [US/US]; 2855 Gazelle Court Carlsbad, CA 92010 (US).
COLD SPRING HARBOR LABORATORY [US/US]; One Bungtown Road Cold Spring Harbor, NY 11724 (US)
Inventors: RIGO, Frank; (US).
KRAINER, Adrian, R.; (US).
JEON, Hyun Yong; (US)
Agent: SCARR, Rebecca; (US)
Priority Data:
62/063,892 14.10.2014 US
Title (EN) ANTISENSE COMPOUNDS AND USES THEREOF
(FR) COMPOSÉS ANTISENS ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention provides compounds comprising oligonucleotides complementary to a pyruvate kinase M transcript. Certain such compounds are useful for hybridizing to a pyruvate kinase M transcript, including but not limited to a pyruvate kinase M transcript in a cell. In certain embodiments, such hybridization results in modulation of splicing of the pyruvate kinase M transcript. In certain embodiments, such compounds are used to treat one or more symptoms associated with cancer.
(FR)La présente invention concerne des composés comprenant des oligonucléotides complémentaires à un produit de transcription d'une pyruvate-kinase M. Certains de ces composés sont utiles pour l'hybridation à un produit de transcription d'une pyruvate-kinase M, incluant, sans y être limité, un produit de transcription d'une pyruvate-kinase M dans une cellule. Dans certains modes de réalisation, une telle hybridation aboutit à la modulation de l'épissage du produit de transcription de la pyruvate-kinase M. Dans certains modes de réalisation, ces composés sont utilisés pour traiter un ou plusieurs symptômes associés au cancer.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)