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1. (WO2016061073) COMPOSITION AND METHOD FOR IN VIVO ENGINEERING OF CHROMOSOMAL REARRANGEMENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/061073    International Application No.:    PCT/US2015/055286
Publication Date: 21.04.2016 International Filing Date: 13.10.2015
IPC:
C12N 15/85 (2006.01), C12N 15/861 (2006.01), C12N 15/113 (2010.01), C12N 15/63 (2006.01)
Applicants: MEMORIAL SLOAN-KETTERING CANCER CENTER [US/US]; Office Of Technology Development 1275 York Avenue, Box 524 New York, NY 10065 (US)
Inventors: VENTURA, Andrea; (US).
MADDALO, Danilo; (US)
Agent: YE, Michael; (US)
Priority Data:
62/063,728 14.10.2014 US
Title (EN) COMPOSITION AND METHOD FOR IN VIVO ENGINEERING OF CHROMOSOMAL REARRANGEMENTS
(FR) COMPOSITION ET TECHNIQUE D'INGÉNIERIE IN VIVO POUR RÉARRANGEMENTS CHROMOSOMIQUES
Abstract: front page image
(EN)A method for inducing specific chromosomal rearrangements in vivo using the CRISPR/Cas system is disclosed. The method may be used to introduce chromosomal rearrangement in vivo and to generate animal models of human diseases, such as a mouse model of Eml4-Alk-driven non- small cell lung cancer.
(FR)L'invention concerne une technique permettant d'induire des réarrangements chromosomiques spécifiques in vivo à l'aide du système CRISPR/Cas. La technique peut être utilisée pour introduire un réarrangement chromosomique in vivo et pour générer des modèles animaux de maladies humaines, tels qu'un modèle murin du cancer du poumon non à petites cellules induit par Eml4-Alk.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)