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1. (WO2016061064) CIRCULATING TUMOR CELL DIAGNOSTICS FOR THERAPY TARGETING PD-L1

Pub. No.:    WO/2016/061064    International Application No.:    PCT/US2015/055275
Publication Date: Fri Apr 22 01:59:59 CEST 2016 International Filing Date: Wed Oct 14 01:59:59 CEST 2015
IPC: G01N 33/574
Applicants: EPIC SCIENCES, INC.
Inventors: DITTAMORE, Ryan
Title: CIRCULATING TUMOR CELL DIAGNOSTICS FOR THERAPY TARGETING PD-L1
Abstract:
The disclosure provides a method for determining if a subject afflicted with cancer is a candidate for Programmed Death Ligand-1 (PD-Ll) targeted immunotherapy, which method comprises (a) providing a liquid biopsy sample obtained from the subject afflicted with cancer; (b) detecting CTCs in the liquid biopsy sample; (c) calculating what proportion of CTCs in the liquid biopsy express PD-Ll; and (c) identifying the subject as a candidate for PD-Ll targeted immunotherapy based on an assessment that the proportion of the CTCs in the liquid biopsy that express PD-Ll exceeds a pre-determined threshold level.