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1. (WO2016060611) AUTOMATIC REGION-OF-INTEREST SEGMENTATION AND REGISTRATION OF DYNAMIC CONTRAST-ENHANCED IMAGES OF COLORECTAL TUMORS

Pub. No.:    WO/2016/060611    International Application No.:    PCT/SG2014/000481
Publication Date: Fri Apr 22 01:59:59 CEST 2016 International Filing Date: Tue Oct 14 01:59:59 CEST 2014
IPC: G06T 7/00
G06K 9/46
G01R 33/20
Applicants: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
Inventors: HOU, Zujun
WANG, Yue
Title: AUTOMATIC REGION-OF-INTEREST SEGMENTATION AND REGISTRATION OF DYNAMIC CONTRAST-ENHANCED IMAGES OF COLORECTAL TUMORS
Abstract:
A method for dynamic contrast enhanced (DCE) image processing and kinetic modeling of an organ's region-of-interest is provided. The method includes deriving at least a contour of an exterior of the organ's region-of-interest from one or more of a plurality of images; generating a spline function in response to the derived contour of the exterior of the organ's region-of-interest from the one or more of the plurality of images; registering the plurality of images wherein the organ's region-of-interest has been segmented; deriving a tracer curve for the organ's region-of-interest in the registered images, the tracer curve indicating a change in concentration of a contrast agent flowing through the organ's region-of-interest over a time period; and kinetic modeling by fitting a kinetic model to the tracer curve to generate one or more maps of tissue physiological parameters associated with the kinetic model.