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1. (WO2016060564) BODY SCULPTING

Pub. No.:    WO/2016/060564    International Application No.:    PCT/NL2015/050722
Publication Date: Fri Apr 22 01:59:59 CEST 2016 International Filing Date: Thu Oct 15 01:59:59 CEST 2015
IPC: A61K 31/23
A61P 3/04
C07C 219/30
A61K 9/00
A61K 9/06
Applicants: SCULPT B.V.
Inventors: CREMERS , Thomas
FLIK, Gunnar
FRIJLINK, Henderik Willem
WOERDENBAG, Herman Johan
The invention pertains to a pharmaceutical composition for topical administration, comprising a prodrug for an agonist and/or an antagonist for an adrenergic receptor, wherein the prodrug has an octanol/water partition coefficient of at least 0, for use in a method of shaping a mammalian body by modulation of subcutaneous fat tissue. The invention further pertains to cosmetic and therapeutic application of such prodrugs, such as their use in methods of shaping a mammalian body by locally modulating subcutaneous fat tissue. The invention also pertains to the prodrugs themselves, as well as to methods of making these prodrugs.