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1. (WO2016060278) METHOD FOR ESTIMATING SENSITIVITY TO DRUG THERAPY FOR COLORECTAL CANCER
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/060278    International Application No.:    PCT/JP2015/079909
Publication Date: 21.04.2016 International Filing Date: 16.10.2015
Chapter 2 Demand Filed:    22.04.2016    
IPC:
C12Q 1/68 (2006.01), C12M 1/00 (2006.01), C12N 15/09 (2006.01), A61K 39/395 (2006.01), A61P 35/00 (2006.01)
Applicants: TOHOKU UNIVERSITY [JP/JP]; 2-1-1, Katahira, Aoba-ku, Sendai-shi, Miyagi 9808577 (JP).
THE UNIVERSITY OF TOKYO [JP/JP]; 3-1, Hongo 7-chome, Bunkyo-ku, Tokyo 1138654 (JP)
Inventors: ISHIOKA, Chikashi; (JP).
TAKAHASHI, Makoto; (JP).
OUCHI, Kouta; (JP).
SHIMODAIRA, Hideki; (JP).
ABURATANI, Hiroyuki; (JP)
Agent: OHNO, Seiji; OHNO & PARTNERS, Marunouchi Kitaguchi Building 21F, 6-5, Marunouchi 1-chome, Chiyoda-ku, Tokyo 1000005 (JP)
Priority Data:
2014-212503 17.10.2014 JP
Title (EN) METHOD FOR ESTIMATING SENSITIVITY TO DRUG THERAPY FOR COLORECTAL CANCER
(FR) PROCÉDÉ D'ESTIMATION DE SENSIBILITÉ À UNE PHARMACOTHÉRAPIE CONTRE LE CANCER COLORECTAL
(JA) 大腸癌に対する薬物療法の感受性を予測する方法
Abstract: front page image
(EN)The present invention relates to a method for estimating responsiveness to cancer drug therapy for colorectal cancer. More specifically, the present invention relates to a method for estimating the responsiveness of a colorectal cancer patient to cancer drug therapy, said method being characterized in that the DNA methylation level in a specimen which includes a colorectal cancer tissue, colorectal cancer cell, or DNA derived from a colorectal cell of a subject is analyzed, and the responsiveness of the subject to cancer drug therapy is determined on the basis of the DNA methylation level.
(FR)L'invention concerne un procédé d'estimation de la faculté de réponse à une pharmacothérapie relative au cancer contre le cancer colorectal. Plus précisément, l'invention concerne un procédé d'estimation de la faculté de réponse à une pharmacothérapie relative au cancer pour un patient atteint du cancer colorectal. Le procédé de l'invention est caractéristique en ce qu'un niveau de méthylation d'ADN dans un échantillon contenant des tissus cancéreux colorectaux, des cellules cancéreuses colorectales, ou de l'ADN dérivé de cellules cancéreuses colorectales appartenant à un sujet, est analysé, et la faculté de réponse à une pharmacothérapie relative au cancer dudit sujet, est jugée sur la base dudit niveau de méthylation d'ADN.
(JA)本発明は、大腸癌に対するがん薬物療法に対する応答性を予測する方法に関する。より詳細には、大腸癌患者のがん薬物療法に対する応答性を予測する方法であって、被験者の大腸癌組織、大腸癌細胞、又は大腸癌細胞由来のDNAを含む検体におけるDNAメチル化レベルを解析し、前記DNAメチル化レベルに基づき前記被験者のがん薬物療法応答性を判定することを特徴とする方法に関する。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)