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1. (WO2016059650) 10-SUBSTITUTED COLCHICINOIDS AS POTENT ANTICANCER AGENTS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/059650 International Application No.: PCT/IN2015/050135
Publication Date: 21.04.2016 International Filing Date: 14.10.2015
IPC:
C07C 233/41 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
233
Carboxylic acid amides
01
having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
34
having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
41
with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
Applicants:
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH [IN/IN]; Anusandhan Bhawan, Rafi Marg, New Delhi 110001, IN
Inventors:
VISHWAKARMA, Ram; IN
BHARATE, Sandip Bibishan; IN
KUMAR, Ajay; IN
SINGH, Baljinder; IN
KUMAR, Ashok; IN
BHUSHAN, Shashi; IN
HAMID, Abid; IN
JOSHI, Prashant; IN
GURU, Santosh Kumar; IN
KUMAR, Suresh; IN
HUSSAIN, Aashiq; IN
QAZI, Asif Khurshid; IN
BHARATE, Sonali Sandip; IN
SHARMA, Parduman; IN
SAXENA, Ajit Kumar; IN
MONDHE, Dilip Manikrao; IN
MAHAJAN, Girish; IN
WANI, Zahoor; IN
Agent:
KOUL, SUNAINA; RCY House, C-235, Defence Colony, New Delhi-110024,, IN
Priority Data:
2929/DEL/201414.10.2014IN
Title (EN) 10-SUBSTITUTED COLCHICINOIDS AS POTENT ANTICANCER AGENTS
(FR) COLCHICINOÏDES SUBSTITUÉS EN POSITION 10, UTILISÉS COMME AGENTS ANTICANCÉREUX PUISSANTS
Abstract:
(EN) The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.
(FR) La présente invention concerne les composés de formule I, dans laquelle R est tel que décrit dans la description. La présente invention concerne en particulier la synthèse et l'activité antiproliférative de colchicinoïdes substitués en position 10. Les composés de l'invention peuvent être utilisés pour la prévention ou dans le traitement d'une maladie cancéreuse.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)