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1. (WO2016059350) PREDICTION OF THE SUSCEPTIBILITY OF AN AT RISK PATIENT TO DEVELOPING OR REDEVELOPING CLOSTRIDIUM DIFFICILE INFECTION
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/059350 International Application No.: PCT/FR2015/052778
Publication Date: 21.04.2016 International Filing Date: 16.10.2015
IPC:
G01N 33/569 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
Applicants:
BIOMÉRIEUX [FR/FR]; 69280 Marcy L'Etoile, FR
Inventors:
FOUSSADIER, Agnès; FR
MILLER, Mark; FR
Agent:
BITAUD, Valérie; FR
Priority Data:
145999617.10.2014FR
Title (EN) PREDICTION OF THE SUSCEPTIBILITY OF AN AT RISK PATIENT TO DEVELOPING OR REDEVELOPING CLOSTRIDIUM DIFFICILE INFECTION
(FR) PRÉDICTION DE LA SUSCEPTIBILITÉ, POUR UN PATIENT À RISQUE, DE DÉVELOPPER OU REDÉVELOPPER UNE INFECTION À CLOSTRIDIUM DIFFICILE
Abstract:
(EN) The present invention relates to a method for prediction of the susceptibility of an at risk patient to developing or redeveloping an infection with Clostridium difficile, comprising the determination by immunoassay, in a stool sample from said patient, of the level of antibody IgA anti-toxin B of Clostridium difficile, and comparing this level with a reference value S determined beforehand using two populations of patients exposed to the bacterium, one population not having developed or redeveloped such an infection and the other population having developed or redeveloped such an infection, - a level lower than said reference value S signifying that the patient is a patient with a heightened risk of developing or redeveloping a Clostridium difficile infection, and - a level higher than said reference value S signifying that the patient is not a patient with a heightened risk of developing or redeveloping a Clostridium difficile infection.
(FR) La présente invention concerne un procédé de prédiction de la susceptibilité, pour un patient à risque, de développer ou redévelopper une infection à Clostridium difficile, comprenant la détermination par immunoessai, dans un échantillon de selles issu dudit patient, du taux en anticorps IgA anti-toxine B de Clostridium difficile, et à comparer ce taux à une valeur de référence S préalablement déterminée avec deux populations de patients exposés à la bactérie, l'une n'ayant pas développé ou redéveloppé une telle infection et l'autre ayant développé ou redéveloppé une telle infection, -un taux inférieur à ladite valeur de référence S signifiant que le patient est un patient à risque accru de développer ou redévelopper une infection à Clostridium difficile, et -un taux supérieur à ladite valeur de référence S signifiant que le patient n'est pas un patient à risque accru de développer ou redévelopper une infection à Clostridium difficile.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)