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1. (WO2016059341) HYBRID PROTEINACEOUS MOLECULE CAPABLE OF INHIBITING AT LEAST ONE ANTIBIOTIC AND PHARMACEUTICAL COMPOSITION CONTAINING IT

Pub. No.:    WO/2016/059341    International Application No.:    PCT/FR2015/052756
Publication Date: Fri Apr 22 01:59:59 CEST 2016 International Filing Date: Wed Oct 14 01:59:59 CEST 2015
IPC: C12N 15/62
C12N 9/86
C12N 15/55
A61K 38/50
C12N 9/12
C12N 15/54
Applicants: AZURRX SAS
Inventors: DUPRET, Daniel
SCHUE, Mathieu
JAIS, Philippe
Title: HYBRID PROTEINACEOUS MOLECULE CAPABLE OF INHIBITING AT LEAST ONE ANTIBIOTIC AND PHARMACEUTICAL COMPOSITION CONTAINING IT
Abstract:
The invention relates to a hybrid proteinaceous molecule comprising at least two proteins capable of inhibiting the activity of at least one antibiotic, the proteins each having different biochemical properties and being bonded to one another. The hybrid proteinaceous molecule inhibits the activity of at least one antibiotic in order to reduce the intestinal side effects of antibiotics, such as severe diarrhoea caused by the antibiotics, and nosocomial infections secondary to parenteral antibiotic therapy.