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1. (WO2016059239) METHODS AND COMPOSITIONS FOR TREATING A SUBJECT WITH A SMAD7 ANTISENSE OLIGONUCLEOTIDE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/059239    International Application No.:    PCT/EP2015/074066
Publication Date: 21.04.2016 International Filing Date: 16.10.2015
IPC:
C12N 15/113 (2010.01), A61K 31/7088 (2006.01), C12Q 1/68 (2006.01)
Applicants: NOGRA PHARMA LIMITED [IE/IE]; 33 Sir John Rogerson's Quay Dublin, 2 (IE)
Inventors: MONTELEONE, Giovanni; (IT)
Agent: LANE, Cathal, M.; (IE)
Priority Data:
62/065,598 17.10.2014 US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING A SUBJECT WITH A SMAD7 ANTISENSE OLIGONUCLEOTIDE
(FR) PROCÉDÉS ET COMPOSITIONS POUR LE TRAITEMENT D'UN SUJET AU MOYEN D'UN OLIGONUCLÉOTIDE ANTISENS DE SMAD7
Abstract: front page image
(EN)The present invention relates to treatment of inflammatory bowel disease (e.g., Crohn's disease and ulcerative colitis) using antisense nucleotides that are directed against polymorphic forms (e.g., those containing single nucleotide polymorphisms) of the SMAD7 mRNA. The invention thus relates to treatment methods for subjects having polymorphic forms of SMAD7 and antisense oligonucleotides that specifically target SMAD7 mRNA transcripts containing polymorphisms.
(FR)La présente invention concerne le traitement d'une maladie intestinale inflammatoire (par exemple, la maladie de Crohn et la rectocolite hémorragique) à l'aide de nucléotides antisens qui sont dirigés contre des formes polymorphes (par exemple, celles contenant des polymorphismes d'un nucléotide simple) de l'ARNm de SMAD7. L'invention concerne donc des méthodes de traitement pour des sujets présentant des formes polymorphes de SMAD7 et des oligonucléotides antisens qui ciblent de manière spécifique des transcripts d'ARNm de SMAD7 contenant des polymorphismes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)