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1. (WO2016059018) DETECTION OF IgM ANTIBODIES USING AN IMMUNE COMPLEX (IC) ELISA

Pub. No.:    WO/2016/059018    International Application No.:    PCT/EP2015/073623
Publication Date: Fri Apr 22 01:59:59 CEST 2016 International Filing Date: Wed Oct 14 01:59:59 CEST 2015
IPC: G01N 33/566
G01N 33/68
Applicants: BERNHARD-NOCHT-INSTITUT FÜR TROPENMEDIZIN
Inventors: EMMERICH-PALOH, Petra
SCHMITZ, Herbert
DESCHERMEIER, Christina
Title: DETECTION OF IgM ANTIBODIES USING AN IMMUNE COMPLEX (IC) ELISA
Abstract:
The present invention relates to the field of diagnostic or analytic methods. In particular, the inventors teach that an Fc receptor for IgM heavy chains (FcμR), in particular, Faim 3/Toso or CD351, or a functional fragment thereof, which preferably comprises the Ig-like domain of Faim 3/Toso, may be used for in vitro quantification of IgM or IgA antibodies, preferably, IgM, in the form of immune complexes, i.e., complexes formed by antigen and specific antibody. These immune complexes may be formed by mixing an antigen with a sample comprising antibodies. A method for detection and quantification of IgA or IgM antibodies in the form of immune complexes is also provided. This can be useful for diagnosis of infections, e.g., with a virus.