WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Options
Query Language
Stem
Sort by:
List Length
Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2016058896) PROCESS FOR THE PREPARATION OF 1-(3,5-DICHLORO-4-FLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/058896 International Application No.: PCT/EP2015/073218
Publication Date: 21.04.2016 International Filing Date: 08.10.2015
IPC:
C07C 45/00 (2006.01) ,C07C 45/63 (2006.01) ,C07C 49/80 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
45
Preparation of compounds having CO groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
61
by reactions not involving the formation of CO groups
63
by introduction of halogen; by substitution of halogen atoms by other halogen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
49
Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
76
Ketones containing a keto group bound to a six-membered aromatic ring
80
containing halogen
Applicants: SYNGENTA PARTICIPATIONS AG[CH/CH]; Schwarzwaldallee 215 CH-4058 Basel, CH
Inventors: SMITS, Helmars; CH
Agent: SYNGENTA INTERNATIONAL AG; Intellectual Property WRO 1008-Z1-26 Schwarzwaldallee 215 4058 Basel, CH
Priority Data:
14188741.414.10.2014EP
Title (EN) PROCESS FOR THE PREPARATION OF 1-(3,5-DICHLORO-4-FLUORO-PHENYL)-2,2,2-TRIFLUORO-ETHANONE
(FR) PROCÉDÉ POUR LA PRÉPARATION DE 1-(3,5-DICHLORO-4-FLUOROPHÉNYL)-2,2,2-TRIFLUOROÉTHANONE
Abstract:
(EN) The invention relates to a a process for the preparation of a compound of formula I comprising a) reacting a compound of formula II in the presence of magnesium or an organometallic reagent of formula III R1M2X (III), wherein R1 is CI-C4alkyl; M2 is Li or Mg and X is halogen or absent; with a compound of formula IV CF3-C(O)-R2 (IV), wherein R2 is halogen, hydroxyl, CI-C4alkoxy, (di-CI-C4alkyl)amino, OC(O)CF3, phenoxy or OM1; wherein M1 is Lithium, Magnesium, Sodium or Potassium; to a compound of formula V, and b) reacting the compound of formula V with alkali metal fluoride in the presence of catalytic amounts of a phase transfer catalyst in the presence of a polar solvent to the compound of formula I.
(FR) L'invention concerne un procédé pour la préparation d'un composé de formule I comprenant les étapes consistant à : a) faire réagir un composé de formule II en présence de magnésium ou d'un réactif organométallique de formule III R1M2X (III), dans laquelle R1 est un alkyle en C1 à C4, M2 est Li ou Mg et X est un halogène ou absent, avec un composé de formule IV CF3-C(O)-R2 (IV), dans laquelle R2 est un halogène, un hydroxyle, un (C1 à C4)alkoxy, un (di-alkyle en C1 à C4)amino, un groupe OC(O)CF3, un phénoxy ou OM1, où M1 est du lithium, du magnésium, du sodium ou du potassium ; pour former un composé de formule V ; et b) faire réagir le composé de formule V avec un fluorure de métal alcalin en présence de quantités catalytiques d'un catalyseur de transfert de phase, en présence d'un solvant polaire, pour obtenir le composé de formule I.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)