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1. (WO2016058537) USES OF ASCL1 IN INDUCING ASTROCYTE TRANSDIFFERENTATION INTO FUNCTIONAL NEURONS
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/058537 International Application No.: PCT/CN2015/091944
Publication Date: 21.04.2016 International Filing Date: 14.10.2015
IPC:
A61K 48/00 (2006.01) ,A61K 38/17 (2006.01) ,A61K 45/00 (2006.01) ,A61P 25/00 (2006.01) ,C12N 15/63 (2006.01) ,C12N 5/10 (2006.01) ,C12Q 1/68 (2006.01) ,C12Q 1/02 (2006.01)
Applicants: SHANGHAI INSTITUTES FOR BIOLOGICAL SCIENCES, CHINESE ACADEMY OF SCIENCES[CN/CN]; 319 Yueyang Road Shanghai 200031, CN
Inventors: CHENG, Leping; CN
ZHANG, Xiaohui; CN
LIU, Yueguang; CN
MIAO, Qinglong; CN
YUAN, Jiacheng; CN
Agent: XU & PARTNERS, LLC.; Room No.106, Building No.1, Universal High-Tech Plaza 958 Zhen Bei Road, Putuo District Shanghai 200333, CN
Priority Data:
201410555115.717.10.2014CN
Title (EN) USES OF ASCL1 IN INDUCING ASTROCYTE TRANSDIFFERENTATION INTO FUNCTIONAL NEURONS
(FR) UTILISATIONS D'ASCL1 DANS L'INDUCTION DE LA TRANSDIFFÉRENCIATION DES ASTROCYTES EN NEURONES FONCTIONNELS
(ZH) Ascl1在诱导星形胶质细胞转分化为功能性神经元中的应用
Abstract:
(EN) Uses of an achaete-scute complex homolog-like 1 (Ascl1) gene or a protein thereof or an accelerator thereof: (i) use in preparing a pharmaceutical composition for inducing astrocytes to become functional neuron cells; and/or (ii) use in preparing a pharmaceutical composition for treating neurological disorders such as neurodegenerative pathologies, central nervous system trauma, and so on.
(FR) L'invention concerne des utilisations d'un gène de type homologue au complexe achaete-scute 1 (Ascl1) ou d'une protéine de celui-ci ou d'un accélérateur de celui-ci : (i) utilisation dans la préparation d'une composition pharmaceutique destinée à induire les astrocytes à devenir des cellules neuronales fonctionnelles; et/ou (ii) utilisation dans la préparation d'une composition pharmaceutique pour le traitement de troubles neurologiques, tels que des pathologies neurodégénératives, des traumatismes du système nerveux central, etc.
(ZH) 一种无刚毛鳞甲复合体同源物样1(achaete-scute complex homolog-like 1,Ascl1)基因或其蛋白或其促进剂的用途,(i)用于制备诱导星形胶质细胞形成功能性神经元细胞的药物组合物;和/或(ii)用于制备治疗神经系统疾病的药物组合物,所述神经系统疾病包括神经退行性病变、中枢神经创伤性疾病等。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)