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|1. (WO2016058501) 5-METHYL-2-(PYRIDINE-2-YLAMINO)-8H-PYRIDINO[2,3-D]PYRIMIDINE-7-ONE COMPOUND|
|Applicants:||SHANGHAI SHALETECH TECHNOLOGY CO., LTD
Provided in the present invention are a series of 5-methyl-2-(pyridine-2-ylamino)-8H-pyridino[2,3-d]pyrimidine-7-one compounds as shown by formula (I), and pharmaceutically acceptable salts, enantiomers, diastereoisomers or racemates, prodrug molecules and solvates thereof, which serve as selective inhibitors of cyclin-dependent kinases CDK4 and/or CDK6, and can be used for treating diseases associated with the signaling pathways of cyclin-dependent kinases. More particularly, the compounds can effectively inhibit the growth of multiple tumour cells, and can be used to prepare anti-tumour drugs for the treatment, combination treatment or prevention of various cancers.