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1. (WO2016058501) 5-METHYL-2-(PYRIDINE-2-YLAMINO)-8H-PYRIDINO[2,3-D]PYRIMIDINE-7-ONE COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/058501    International Application No.:    PCT/CN2015/091668
Publication Date: 21.04.2016 International Filing Date: 10.10.2015
IPC:
C07D 471/04 (2006.01), C07D 519/00 (2006.01), A61K 31/519 (2006.01), A61K 31/5383 (2006.01), A61K 31/551 (2006.01), A61P 35/00 (2006.01), A61P 35/02 (2006.01)
Applicants: SHANGHAI SHALETECH TECHNOLOGY CO., LTD [CN/CN]; Room 710, 780 Cailun Road, Pudong Shanghai 201203 (CN)
Inventors: JIANG, Yueheng; (CN)
Agent: KINGSOUND & PARTNERS; 11/F, Block B, KingSound International Center, 116 Zizhuyuan Road, Haidian District Beijing 100097 (CN)
Priority Data:
201410548970.5 16.10.2014 CN
Title (EN) 5-METHYL-2-(PYRIDINE-2-YLAMINO)-8H-PYRIDINO[2,3-D]PYRIMIDINE-7-ONE COMPOUND
(FR) COMPOSÉ 5-MÉTHYL-2-(PYRIDINE-2-YLAMINO)-8H-PYRIDINO[2,3-D]PYRIMIDINE-7-ONE
(ZH) 5-甲基-2-(吡啶-2-基氨基)-8H-吡啶并[2,3-d]嘧啶-7-酮化合物
Abstract: front page image
(EN)Provided in the present invention are a series of 5-methyl-2-(pyridine-2-ylamino)-8H-pyridino[2,3-d]pyrimidine-7-one compounds as shown by formula (I), and pharmaceutically acceptable salts, enantiomers, diastereoisomers or racemates, prodrug molecules and solvates thereof, which serve as selective inhibitors of cyclin-dependent kinases CDK4 and/or CDK6, and can be used for treating diseases associated with the signaling pathways of cyclin-dependent kinases. More particularly, the compounds can effectively inhibit the growth of multiple tumour cells, and can be used to prepare anti-tumour drugs for the treatment, combination treatment or prevention of various cancers.
(FR)La présente invention concerne une série de composés 5-méthyl-2-(pyridine-2-ylamino)-8H-pyridino[2,3-d]pyrimidine-7-one tels que présentés par la formule (I), et leurs sels, énantiomères, diastéréo-isomères ou racémates pharmaceutiquement acceptables, leurs molécules promédicaments et solvates, qui servent d'inhibiteurs sélectifs des CDK4 et/ou CDK6 kinases dépendantes de la cycline, et qui peuvent être utilisés pour traiter les maladies associées aux voies de signalisation des kinases dépendantes de la cycline. Plus particulièrement, les composés peuvent efficacement inhiber le développement de multiple cellules tumorales, et peuvent être utilisés pour préparer des médicaments antitumoraux pour le traitement, la polythérapie ou la prévention de divers cancers.
(ZH)本发明提供了式(I)所示的一系列5-甲基-2-(吡啶-2-基氨基)-8H-吡啶并[2,3-d]嘧啶-7-酮类化合物、其药学上可接受的盐、对映异构体、非对映异构体或外消旋体、前药分子和溶剂合物,其作为细胞周期蛋白依赖性激酶CDK4和/或CDK6选择性抑制剂,可用于治疗与细胞周期蛋白依赖性激酶信号通路有关的疾病。更特别地,该类化合物可有效抑制多种肿瘤细胞的生长,可用于制备抗肿瘤药物,用于不同的癌症的治疗、联合治疗或预防。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)