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1. (WO2016058501) 5-METHYL-2-(PYRIDINE-2-YLAMINO)-8H-PYRIDINO[2,3-D]PYRIMIDINE-7-ONE COMPOUND

Pub. No.:    WO/2016/058501    International Application No.:    PCT/CN2015/091668
Publication Date: Fri Apr 22 01:59:59 CEST 2016 International Filing Date: Sun Oct 11 01:59:59 CEST 2015
IPC: C07D 471/04
C07D 519/00
A61K 31/519
A61K 31/5383
A61K 31/551
A61P 35/00
A61P 35/02
Applicants: SHANGHAI SHALETECH TECHNOLOGY CO., LTD
上海页岩科技有限公司
Inventors: JIANG, Yueheng
江岳恒
Title: 5-METHYL-2-(PYRIDINE-2-YLAMINO)-8H-PYRIDINO[2,3-D]PYRIMIDINE-7-ONE COMPOUND
Abstract:
Provided in the present invention are a series of 5-methyl-2-(pyridine-2-ylamino)-8H-pyridino[2,3-d]pyrimidine-7-one compounds as shown by formula (I), and pharmaceutically acceptable salts, enantiomers, diastereoisomers or racemates, prodrug molecules and solvates thereof, which serve as selective inhibitors of cyclin-dependent kinases CDK4 and/or CDK6, and can be used for treating diseases associated with the signaling pathways of cyclin-dependent kinases. More particularly, the compounds can effectively inhibit the growth of multiple tumour cells, and can be used to prepare anti-tumour drugs for the treatment, combination treatment or prevention of various cancers.