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1. (WO2016058472) VITAMIN D2 AND VITAMIN D3 EUTECTIC CRYSTAL AND PREPARATION METHOD AND USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/058472    International Application No.:    PCT/CN2015/090212
Publication Date: 21.04.2016 International Filing Date: 22.09.2015
IPC:
C07C 401/00 (2006.01), A61K 31/593 (2006.01), A61P 19/08 (2006.01)
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 555 Zuchongzhi Road, Zhangjiang, Pudong Shanghai 201203 (CN)
Inventors: MEI, Xuefeng; (CN).
WANG, Jianrong; (CN).
ZHU, Bingqing; (CN).
LI, Sha; (CN)
Agent: KINGSOUND & PARTNERS; 11/F, Block B, KingSound International Center, 116 Zizhuyuan Road, Haidian District Beijing 100097 (CN)
Priority Data:
201410546268.5 15.10.2014 CN
Title (EN) VITAMIN D2 AND VITAMIN D3 EUTECTIC CRYSTAL AND PREPARATION METHOD AND USE THEREOF
(FR) CRISTAL D'EUTECTIQUE DE VITAMINE D2 ET VITAMINE D3, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
(ZH) 维生素D2与D3的共晶及其制备方法和用途
Abstract: front page image
(EN)Provided are a vitamin D2 and vitamin D3 eutectic crystal, a preparation method and use thereof, and a pharmaceutical composition comprising the eutectic crystal. The vitamin D2 and vitamin D3 eutectic crystal has the advantages of a high degree of crystallinity and low hygroscopicity and forms a neat crystal type form, and the stability is improved remarkably, so that fabrication processing of medicines and improvement of the physicochemical properties are facilitated and the performance of the prepared medicine is improved.
(FR)L'invention concerne un cristal d'eutectique de vitamine D2 et de vitamine D3, son procédé de préparation et son utilisation, ainsi qu'une composition pharmaceutique comprenant le cristal d'eutectique. Le cristal d'eutectique de vitamine D2 et de vitamine D3 présente les avantages d'un degré élevé de cristallinité et de faible capacité hygroscopique et forme une forme de type cristal pur, et la stabilité est considérablement améliorée, de sorte que le traitement de fabrication de médicaments et l'amélioration des propriétés physico-chimiques sont facilités et que les performances du médicament préparé sont améliorées.
(ZH)提供了一种维生素D 2和D 3的共晶、其制备方法和用途,以及包含所述共晶的药物组合物。所述维生素D 2与D 3的共晶具有结晶度高、吸湿性小的优点,并形成规整的晶体型态,稳定性显著增强,因而有利于药物的工艺处理和物化性能的改善,提高成药性能。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)