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1. (WO2016057871) ANTIOXIDANT EYE DROPS

Pub. No.:    WO/2016/057871    International Application No.:    PCT/US2015/054841
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Sat Oct 10 01:59:59 CEST 2015
IPC: A61K 31/14
A61K 36/82
A61K 31/19
A61K 31/05
A61K 9/08
A61K 47/10
Applicants: KADOR, Peter F.
Inventors: KADOR, Peter F.
Title: ANTIOXIDANT EYE DROPS
Abstract:
The antioxidant eye drops is a topical ophthalmic formulation that contains four nutraceuticals (namely, astaxanthin, resveratrol, pyruvate and epigallocatechin gallate (EGCG)) having antioxidant, anti-inflammatory, and chelating activity in a carbomer gel carrier. The active ingredients can reduce oxidative stress through free radical scavenging and chelating activity. The carrier is composed of a solution of deionized water containing about 0.4% Carbopol 980 NF, 5.7% sorbitol. 0.01% cetrimide, 0.01% EDTA, and sodium chloride and sodium hydroxide in adequate amounts to adjust both the viscosity and the pH of the topical carrier to pH 7.0-7.4. Use of the formulation may delay the development of cataracts, reduce retinal degeneration, and maintain normal tear flow in dry eye due to the antioxidant, anti-inflammatory, and chelating activity of the active ingredients.