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1. (WO2016057841) COMPOSITIONS AND METHODS OF USE FOR AUGMENTED IMMUNE RESPONSE AND CANCER THERAPY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/057841    International Application No.:    PCT/US2015/054770
Publication Date: 14.04.2016 International Filing Date: 08.10.2015
IPC:
C07K 16/28 (2006.01), A61K 39/00 (2006.01)
Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35 CH-4056 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
BROGDON, Jennifer [US/US]; (US) (US only).
CIPOLLETTA, Daniela [IT/US]; (US) (US only).
DRANOFF, Glenn [US/US]; (US) (US only).
KNEE, Deborah A. [GB/US]; (US) (US only).
WANG, Fei [US/US]; (US) (US only)
Inventors: BROGDON, Jennifer; (US).
CIPOLLETTA, Daniela; (US).
DRANOFF, Glenn; (US).
KNEE, Deborah A.; (US).
WANG, Fei; (US)
Agent: SCHRAY, Kerri Pollard; (US)
Priority Data:
62/061,644 08.10.2014 US
62/198,673 29.07.2015 US
62/220,764 18.09.2015 US
Title (EN) COMPOSITIONS AND METHODS OF USE FOR AUGMENTED IMMUNE RESPONSE AND CANCER THERAPY
(FR) COMPOSITIONS ET PROCÉDÉS D'UTILISATION POUR UNE RÉPONSE IMMUNITAIRE ACCRUE ET UNE THÉRAPIE ANTICANCÉREUSE
Abstract: front page image
(EN)The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis factor receptor superfamily member (i.e., 18), and compositions comprising one or more additional therapeutic agents. Provided compositions are useful in enhancing CD4+ and CD8+ T cell responses, and in the treatment, amelioration and prevention of diseases that can be counteracted with an augmented immune response, e.g., cancers. Also provided are methods of use of combinations that find use in treatment or prevention of cancerous or infectious conditions and disorders.
(FR)La présente invention concerne des compositions d'anticorps, comprenant, par exemple, des anticorps, des anticorps modifiés et des fragments d'anticorps se liant à un membre de la superfamille du récepteur du facteur de nécrose tumorale (c'est-à-dire, 18), et des compositions comprenant un ou plusieurs agents thérapeutiques supplémentaires. Les compositions selon l'invention sont utiles dans l'amélioration des réponses à cellules T CD4+ et CD8+, et dans le traitement, l'amélioration et la prévention de maladies qui peuvent être contrecarrées par une réponse immune accrue, par exemple, des cancers. L'invention concerne également des procédés d'utilisation de combinaisons qui trouvent une utilisation dans le traitement ou la prévention d'affections et de troubles cancéreux ou infectieux.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)