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1. (WO2016057841) COMPOSITIONS AND METHODS OF USE FOR AUGMENTED IMMUNE RESPONSE AND CANCER THERAPY

Pub. No.:    WO/2016/057841    International Application No.:    PCT/US2015/054770
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Fri Oct 09 01:59:59 CEST 2015
IPC: C07K 16/28
A61K 39/00
Applicants: NOVARTIS AG
BROGDON, Jennifer
CIPOLLETTA, Daniela
DRANOFF, Glenn
KNEE, Deborah A.
WANG, Fei
Inventors: BROGDON, Jennifer
CIPOLLETTA, Daniela
DRANOFF, Glenn
KNEE, Deborah A.
WANG, Fei
Title: COMPOSITIONS AND METHODS OF USE FOR AUGMENTED IMMUNE RESPONSE AND CANCER THERAPY
Abstract:
The present invention provides antibody compositions, including, e.g., antibodies, engineered antibodies and antibody fragments that bind to a tumor necrosis factor receptor superfamily member (i.e., 18), and compositions comprising one or more additional therapeutic agents. Provided compositions are useful in enhancing CD4+ and CD8+ T cell responses, and in the treatment, amelioration and prevention of diseases that can be counteracted with an augmented immune response, e.g., cancers. Also provided are methods of use of combinations that find use in treatment or prevention of cancerous or infectious conditions and disorders.