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1. (WO2016057832) METHOD FOR IDENTIFICATION AND QUANTIFICATION OF NUCLEIC ACID EXPRESSION, SPLICE VARIANT, TRANSLOCATION, COPY NUMBER, OR METHYLATION CHANGES

Pub. No.:    WO/2016/057832    International Application No.:    PCT/US2015/054759
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Fri Oct 09 01:59:59 CEST 2015
IPC: C12Q 1/68
Applicants: CORNELL UNIVERSITY
Inventors: BARANY, Francis
EFCAVITCH, John, William
RUIZ RUEDA, Cristian
HUANG, Jianmin
FEINBERG, Philip, B.
Title: METHOD FOR IDENTIFICATION AND QUANTIFICATION OF NUCLEIC ACID EXPRESSION, SPLICE VARIANT, TRANSLOCATION, COPY NUMBER, OR METHYLATION CHANGES
Abstract:
The present invention relates to methods and devices for identifying and quantifying, including low abundance, nucleotide base mutations, insertions, deletions, translocations, splice variants, miRNA variants, alternative transcripts, alternative start sites, alternative coding sequences, alternative non-coding sequences, alternative splicings, exon insertions, exon deletions, intron insertions, or other rearrangement at the genome level and/or methylated nucleotide bases.