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1. (WO2016057800) TARGETED DISRUPTION OF A CSF1-DAP12 PATHWAY MEMBER GENE FOR THE TREATMENT OF NEUROPATHIC PAIN

Pub. No.:    WO/2016/057800    International Application No.:    PCT/US2015/054704
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Fri Oct 09 01:59:59 CEST 2015
IPC: A61K 48/00
C12N 15/11
C12N 5/02
C12N 15/00
C07H 21/04
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: BASBAUM, Allan
KUHN, Julia
GUAN, Zhonghui
Title: TARGETED DISRUPTION OF A CSF1-DAP12 PATHWAY MEMBER GENE FOR THE TREATMENT OF NEUROPATHIC PAIN
Abstract:
The invention provides compositions and methods for treating neuropathic pain. Specifically, the disclosure provides a polynucleotide comprising a trigeminal ganglion (TGG) or dorsal root ganglion (DRG) promoter operably linked to a recombinant nucleic acid encoding an endonuclease that binds to a nucleotide sequence in the human colony stimulating factor 1 (hCSF1 ) gene and a method of using the polynucleotide or a vector comprising the polynucleotide for treatment of neuropathic pain.