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1. (WO2016057754) ANTIBIOTIC ACTIVITY OF IRON SEQUESTRING POLYMERS

Pub. No.:    WO/2016/057754    International Application No.:    PCT/US2015/054627
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Fri Oct 09 01:59:59 CEST 2015
IPC: A61K 31/785
A61K 47/48
C08G 59/50
Applicants: THE UNIVERSITY OF KANSAS
Inventors: BERKLAND, Cory
RIVERA, Mario
ESHELMAN, Kate
QIAN, Jian
EL-GENDY, Nashwa
Title: ANTIBIOTIC ACTIVITY OF IRON SEQUESTRING POLYMERS
Abstract:
A polymeric metal sequestrant providing antibiotic activity is provided. The polymeric metal sequestrant comprises a polyamine polymer covalently coupled to a chelator, wherein the chelator has a benzene ring with more than one hydroxyl group at any position that is free. The polymeric metal sequestrant is effective in inhibiting and preventing bacterial infections and displays synergistic effects in combination with traditional antibiotics.