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1. (WO2016057754) ANTIBIOTIC ACTIVITY OF IRON SEQUESTRING POLYMERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/057754    International Application No.:    PCT/US2015/054627
Publication Date: 14.04.2016 International Filing Date: 08.10.2015
IPC:
A61K 31/785 (2006.01), A61K 47/48 (2006.01), C08G 59/50 (2006.01)
Applicants: THE UNIVERSITY OF KANSAS [US/US]; 1450 Jayhawk Boulevard 245 Strong Hall Lawrence, KS 66045 (US)
Inventors: BERKLAND, Cory; (US).
RIVERA, Mario; (US).
ESHELMAN, Kate; (US).
QIAN, Jian; (CN).
EL-GENDY, Nashwa; (US)
Agent: GIBSON, Matthew, S.; (US)
Priority Data:
62/062,779 10.10.2014 US
Title (EN) ANTIBIOTIC ACTIVITY OF IRON SEQUESTRING POLYMERS
(FR) ACTIVITÉ ANTIBIOTIQUE DE POLYMÈRES SÉQUESTRANT LE FER
Abstract: front page image
(EN)A polymeric metal sequestrant providing antibiotic activity is provided. The polymeric metal sequestrant comprises a polyamine polymer covalently coupled to a chelator, wherein the chelator has a benzene ring with more than one hydroxyl group at any position that is free. The polymeric metal sequestrant is effective in inhibiting and preventing bacterial infections and displays synergistic effects in combination with traditional antibiotics.
(FR)La présente invention concerne un séquestrant de métal polymère produisant une activité antibiotique. Le séquestrant de métal polymère comprend un polymère de polyamine couplé de façon covalente à un chélateur, où le chélateur comporte un cycle benzénique comportant plus d'un groupe hydroxyle à une position quelconque qui est libre. Le séquestrant de métal polymère est efficace dans l’inhibition et la prévention d’infections bactériennes et présente des effets synergiques en combinaison avec des antibiotiques conventionnels.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)