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1. (WO2016057730) CO-CRYSTALS OF MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

Pub. No.:    WO/2016/057730    International Application No.:    PCT/US2015/054577
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Thu Oct 08 01:59:59 CEST 2015
IPC: C07D 215/56
Applicants: VERTEX PHARMACEUTICALS INCORPORATED
Inventors: STROHMEIER, Mark
CAESAR, JR., John P.
CONNELLY, Patrick Raymond
FAWAZ, Majed
LUSS-LUSIS, Eduard
MCCLAIN, Brian R.
MEDEK, Ales
MIAO, Hai
NTI-ADDAE, Kwame Wiredu
YIN, Ping
ZHANG, Yuegang
Title: CO-CRYSTALS OF MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
Abstract:
The present disclosure relates to co-crystals comprising N-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide (Compound 1) and a co-former and methods for their preparation. The present disclosure further relates to pharmaceutical compositions comprising the co-crystal forms, as well as methods of treatment therewith and kits.