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1. (WO2016057571) ENGINEERED RENAL TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/057571 International Application No.: PCT/US2015/054315
Publication Date: 14.04.2016 International Filing Date: 06.10.2015
IPC:
C12N 5/07 (2010.01) ,C12N 5/09 (2010.01) ,G01N 33/50 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
09
Tumour cells
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
Applicants:
ORGANOVO, INC. [US/US]; 6275 Nancy Ridge Drive Suite 110 San Diego, California 92121, US
Inventors:
NGUYEN, Deborah Lynn Greene; US
KING, Shelby Marie; US
PRESNELL, Sharon C.; US
Agent:
STERLING, Deborah A., Esq.; US
Priority Data:
62/060,41606.10.2014US
62/140,28530.03.2015US
Title (EN) ENGINEERED RENAL TISSUES, ARRAYS THEREOF, AND METHODS OF MAKING THE SAME
(FR) TISSUS RÉNAUX PRODUITS PAR GÉNIE GÉNÉTIQUE, RÉSEAUX CORRESPONDANTS, ET PROCÉDÉS DE PRODUCTION
Abstract:
(EN) Disclosed are renal tissues and arrays thereof that include a layer of renal interstitial tissue, the renal interstitial tissue comprising renal fibroblasts and endothelial cells; and a layer of renal epithelial tissue, the renal epithelial tissue comprising renal tubular epithelial cells, the renal epithelial tissue in contact with the layer of renal interstitial tissue to form a three-dimensional, engineered, biological renal tissue. Also disclosed are methods of fabricating and using the same.
(FR) L'invention concerne des tissus rénaux et des réseaux de ces derniers qui comprennent une couche de tissus interstitiels rénaux, les tissus interstitiels rénaux comprenant des fibroblastes rénaux et des cellules endothéliales, et une couche de tissu épithéliaux rénaux, les tissus épithéliaux rénaux comprenant des cellules épithéliales tubulaires rénales et les les tissus épithéliaux rénaux étant en contact avec la couche de tissus interstitiels rénaux afin de former des tissus rénaux biologiques obtenus par génie génétique et tridimensionnels. L'invention concerne également des procédés de fabrication et d'utilisation de ces derniers.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)