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1. (WO2016057413) INHIBITORS OF LYSINE GINGIPAIN

Pub. No.:    WO/2016/057413    International Application No.:    PCT/US2015/054050
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Tue Oct 06 01:59:59 CEST 2015
IPC: C07C 233/62
Applicants: CORTEXYME, INC.
Inventors: KONRADI, Andrei
DOMINY, Stephen S.
CRAWFORD LYNCH, Casey
COBURN, Craig
VACCA, Joseph
Title: INHIBITORS OF LYSINE GINGIPAIN
Abstract:
The present invention relates generally to therapeutics targeting the bacterium Porphyromonas gingivalis, including its protease Lysine gingipain (Kgp), and their use for the treatment of disorders associated with P. gingivalis infection, including brain disorders such as Alzheimers disease. In certain embodiments, the invention provides compounds according to Formula (I), as described herein, and pharmaceutically acceptable salts thereof.