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1. (WO2016057278) AMINOPYRIDYLOXYPYRAZOLE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/057278    International Application No.:    PCT/US2015/053098
Publication Date: 14.04.2016 International Filing Date: 30.09.2015
IPC:
C07D 401/14 (2006.01), C07D 405/14 (2006.01), C07D 401/12 (2006.01), A61K 31/454 (2006.01), A61K 31/4545 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01)
Applicants: ELI LILLY AND COMPANY [US/US]; Lilly Corporate Center Indianapolis, Indiana 46285 (US)
Inventors: BEIGHT, Douglas W.; (US).
COATES, David A.; (US).
JOSEPH, Sajan; (US).
MCMILLEN, William T.; (US).
PARTHASARATHY, Saravanan; (US).
PEI, Huaxing; (US).
SAWYER, Jason Scott; (US).
WOLFANGEL, Craig D.; (US).
ZHAO, Gaiying; (US)
Agent: TUCKER, Tina M.; (US)
Priority Data:
62/060,724 07.10.2014 US
Title (EN) AMINOPYRIDYLOXYPYRAZOLE COMPOUNDS
(FR) COMPOSÉS D'AMINOPYRIDYLOXYPYRAZOLE
Abstract: front page image
(EN)The present invention relates to novel aminopyridyloxypyrazole compounds that inhibit the activity of transforming growth factor beta receptor 1 (TGFpRI), pharmaceutical compositions comprising the compounds, and methods of using the compounds to treat cancer, preferably colon cancer, melanoma, hepatocellular carcinoma, renal cancer, glioblastoma, pancreatic cancer, myelodysplastic syndrome, lung cancer, and gastric cancer, and/or fibrosis, preferably liver fibrosis and chronic kidney disease.
(FR)La présente invention concerne de nouveaux composés d'aminopyridyloxypyrazole qui inhibent l'activité du récepteur 1 du facteur de croissance transformant bêta (TGFpRI), des compositions pharmaceutiques comprenant les composés et des procédés d'utilisation des composés pour traiter le cancer, de préférence cancer du côlon, mélanome, carcinome hépatocellulaire, cancer rénal, glioblastome, cancer du pancréas, syndrome myélodysplasique, cancer du poumon et cancer gastrique et/ou la fibrose, de préférence cirrhose du foie et maladie rénale chronique.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)