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1. (WO2016057242) HIF-2α INHIBITORS FOR TREATING IRON OVERLOAD DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/057242    International Application No.:    PCT/US2015/052279
Publication Date: 14.04.2016 International Filing Date: 25.09.2015
IPC:
A61K 31/075 (2006.01), A61K 31/381 (2006.01)
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM [US/US]; 201 W. 7th Street Austin, TX 78701 (US)
Inventors: BRUICK, Richard, Keith; (US).
CHEN, Yaomin; (US).
RUIZ, Julio, Cesar, Francisco; (US)
Agent: HIGHLANDER, Steven, L.; (US)
Priority Data:
62/062,419 10.10.2014 US
Title (EN) HIF-2α INHIBITORS FOR TREATING IRON OVERLOAD DISORDERS
(FR) INHIBITORS HIF-2Α POUR TRAITER DES TROUBLES D'HÉMOCHROMATOSE
Abstract: front page image
(EN)The present disclosure relates to HIF-2α inhibitors and methods of making and using them for treating iron overload disorders. Certain compounds were potent in HIF-2α scintillation proximity assay, luciferase assay, and VEGF ELISA assay, and reduced liver iron accumulation and serum iron parameters in both prophylactic and treatment mouse models.
(FR)L'invention concerne des inhibiteurs de HIF-2α et des procédés permettant de les fabriquer et de les utiliser pour traiter des troubles d'hémochromatose. Certains composés se sont avérés efficaces dans un dosage de proximité de scintillation de HIF-2α, un dosage de luciférase, un dosage ELISA VEGF, et ont réduit l'accumulation de fer dans le foie et les paramètres de fer sérique chez des modèles murins à la fois prophylactiques et thérapeutiques.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)