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1. (WO2016057061) EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES IN VITRO AND IN VIVO
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/057061 International Application No.: PCT/US2015/000109
Publication Date: 14.04.2016 International Filing Date: 09.10.2015
IPC:
A61K 38/17 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
Applicants:
MASSACHUSETTS EYE AND EAR INFIRMARY [US/US]; 325 Charles Street, 6th Floor Boston, MA 02114, US
Inventors:
CHEN, Zheng-Yi; US
LIU, David; US
Agent:
ZACHARIADES, Nicholas, A.; US
Priority Data:
62/062,62810.10.2014US
Title (EN) EFFICIENT DELIVERY OF THERAPEUTIC MOLECULES IN VITRO AND IN VIVO
(FR) ADMINISTRATION EFFICACE DE MOLÉCULES THÉRAPEUTIQUES IN VITRO ET IN VIVO
Abstract:
(EN) A chimeric molecule of one or more proteins or peptides fused, complexed or linked to one or more anionic molecules. Efficient in vitro and in vivo delivery is attained by encapsulating these molecules in cationic lipids or cationic liposomes. Methods of treatment include the intracellular delivery of these molecules to a specific therapeutic target.
(FR) La présente invention concerne une molécule chimère d'une ou de plusieurs protéines ou d'un ou plusieurs peptides fusionnés, complexés ou liés à une ou plusieurs molécules anioniques. Une distribution efficace in vitro et in vivo est obtenue par encapsulation de ces molécules dans des lipides cationiques ou des liposomes cationiques. Des procédés de traitement comprennent l'administration intracellulaire de ces molécules à une cible thérapeutique spécifique.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)