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1. (WO2016056658) METHOD FOR PURIFYING STATIN COMPOUND
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/056658 International Application No.: PCT/JP2015/078822
Publication Date: 14.04.2016 International Filing Date: 09.10.2015
IPC:
C07D 209/24 (2006.01) ,A61K 31/404 (2006.01) ,A61K 31/47 (2006.01) ,A61K 31/505 (2006.01) ,A61P 3/06 (2006.01) ,A61P 43/00 (2006.01) ,C07D 215/14 (2006.01) ,C07D 239/42 (2006.01) ,C12N 9/04 (2006.01) ,C12N 15/09 (2006.01)
Applicants: API CORPORATION[JP/JP]; 13-4, Uchikanda 1-chome, Chiyoda-ku, Tokyo 1010047, JP
Inventors: OHTANI, Takashi; JP
NAGAHAMA, Masaki; JP
WATANABE, Naoyuki; JP
Agent: TAKASHIMA, Hajime; JP
Priority Data:
2014-20948110.10.2014JP
Title (EN) METHOD FOR PURIFYING STATIN COMPOUND
(FR) PROCÉDÉ DE PURIFICATION DE COMPOSÉ STATINE
(JA) スタチン系化合物の精製方法
Abstract: front page image
(EN)  Provided is a method with which it is possible to efficiently improve the purity of a stain compound. A method for purifying a statin compound including a compound represented by general formula (1): (in the formula, R1 is a group including a nitrogen-containing heterocycle, R2 is a C1-4 alkyl group, alkali metal element, alkaline earth metal element, or hydrogen), wherein the method for purifying a statin compound is characterized by including (A) a step for converting a compound represented by general formula (1) into a compound represented by general formula (2): (in the formula, R1 is defined in the same way as above.).
(FR)  L'invention concerne un procédé permettant d'améliorer efficacement la pureté d'un composé statine. Un procédé de purification d'un composé statine comprenant un composé représenté par la formule générale (1) : (dans la formule, R1 représente un groupe comprenant un hétérocycle contenant de l'azote, R2 représente un groupe alkyle en C1-4, un élément métal alcalin, un élément métal alcalino-terreux, ou un atome d'hydrogène), le procédé de purification d'un composé statine étant caractérisé en ce qu'il comprend (A) une étape de conversion d'un composé représenté par la formule générale (1) en un composé représenté par la formule générale (2) : (dans la formule, R1 est défini de la même manière que ci-dessus).
(JA)  スタチン系化合物の純度を、効率よく向上させることができる精製方法を提供すること。下記一般式(1):(式中、Rは、窒素含有複素環を含む基であり、Rは、炭素数1~4のアルキル基、アルカリ金属元素、アルカリ土類金属元素、または水素である。) で表される化合物を含む、スタチン系化合物の精製方法であって、 (A)該一般式(1)で表される化合物を、下記一般式(2):(式中、Rは、前記と同義である。) で表される化合物に変換する工程 を有することを特徴とする、スタチン系化合物の精製方法。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)