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1. (WO2016055996) EXPANDING T CELL POPULATIONS USING BIPHOSPHONATES, ANTI CD 3 ANTIBODY AND IL-2
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/055996 International Application No.: PCT/IL2015/050977
Publication Date: 14.04.2016 International Filing Date: 24.09.2015
IPC:
C12N 5/0783 (2010.01) ,A61K 35/17 (2015.01) ,A61P 37/06 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07
Animal cells or tissues
071
Vertebrate cells or tissues, e.g. human cells or tissues
078
Cells from blood or from the immune system
0783
T cells; NK cells; Progenitors of T or NK cells
[IPC code unknown for A61K 35/17]
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
06
Immunosuppressants, e.g. drugs for graft rejection
Applicants:
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. [IL/IL]; Tel Hashomer The Chaim Sheba Medical Center 52621 Ramat Gan, IL
Inventors:
BANK, Ilan; IL
BESSER, Michal; IL
MARCU, Victoria; IL
Agent:
WEBB, Cynthia; IL
Priority Data:
62/060,02706.10.2014US
Title (EN) EXPANDING T CELL POPULATIONS USING BIPHOSPHONATES, ANTI CD 3 ANTIBODY AND IL-2
(FR) ACCROISSEMENT DE POPULATIONS DE LYMPHOCYTES T À L'AIDE DE BIPHOSPHONATES, D'ANTICORPS ANTI-CD3 ET DE IL-2
Abstract:
(EN) The present invention provides methods for expanding populations of T cells, including gamma delta T cells, by incubating peripheral blood mononuclear cells with biphosphonates and then with anti CD3 antibody and IL-2. Pharmaceutical compositions comprising the expanded T cells for treating infectious, autoimmune and malignant diseases are also provided.
(FR) La présente invention concerne des procédés permettant d'accroître des populations de lymphocytes T, y compris de lymphocytes T gamma delta, par incubation de cellules mononucléaires de sang périphérique avec des biphosphonates, puis avec des anticorps anti-CD3 et avec IL -2 Elle concerne également des compositions pharmaceutiques comprenant lesdites cellules T accrues pour traiter des maladies infectieuses, auto-immunes et malignes.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)