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1. (WO2016055935) COMBINATION OF LYSINE-SPECIFIC DEMETHYLASE 1 INHIBITOR AND THROMBOPOIETIN AGONIST

Pub. No.:    WO/2016/055935    International Application No.:    PCT/IB2015/057637
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Wed Oct 07 01:59:59 CEST 2015
IPC: A61K 45/06
A61K 31/4152
A61K 31/445
A61P 35/00
A61P 35/02
Applicants: GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED
Inventors: ERICKSON-MILLER, Connie L.
KRUGER, Ryan G.
STONE, Nicole Lee
Title: COMBINATION OF LYSINE-SPECIFIC DEMETHYLASE 1 INHIBITOR AND THROMBOPOIETIN AGONIST
Abstract:
The present invention relates to a method of treating cancer and pre-cancerous syndromes in a human and to pharmaceutical combinations useful in such treatment. In particular, the method relates to a cancer treatment method that includes administering 4- ((4-((((1R,2S)-2-phenylcyclopropyl)amino)methyl)piperidin-1-yl)methyl)benzoic acid, or a pharmaceutically acceptable salt thereof, and 3'-[(2Z)-[1-(3,4-dimethylphenyl)-1,5-dihydro-3-methyl-5-oxo-4H-pyrazol-4-ylidene]hydrazin o]-2'-hydroxy-[1,1'-biphenyl]-3-carboxylic acid, or a pharmaceutically acceptable salt thereof, to a human in need thereof.