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Machine translation
1. (WO2016055907) SYNERGISTIC AURISTATIN COMBINATIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/055907    International Application No.:    PCT/IB2015/057457
Publication Date: 14.04.2016 International Filing Date: 29.09.2015
IPC:
A61K 31/4015 (2006.01), A61K 31/4025 (2006.01), A61K 45/06 (2006.01), A61K 31/166 (2006.01), A61P 35/00 (2006.01)
Applicants: PFIZER INC. [US/US]; 235 East 42nd Street New York, New York 10017 (US)
Inventors: SAPRA, Puja; (US).
SHOR, Boris; (US)
Agent: PUGMIRE, Matthew J.; (US)
Priority Data:
62/062,192 10.10.2014 US
Title (EN) SYNERGISTIC AURISTATIN COMBINATIONS
(FR) ASSOCIATIONS SYNERGIQUES D'AURISTATINE
Abstract: front page image
(EN)This invention relates to combinations of an auristatin or an auristatin-based antibody-drug-conjugate (ADC) with second active agents including PI3K/mTOR inhibitors, MEK inhibitors, taxanes, or other anti-cancer agents, and methods of treating abnormal cell growth by administering these combinations to patients.
(FR)La présente invention concerne des associations d'une auristatine ou d'un anticorps conjugué à des cytotoxiques (ADC) à base d'auristatine avec des seconds agents actifs comprenant des inhibiteurs de PI3K/mTOR, des inhibiteurs de MEK, des taxanes, ou d'autres agents anti-cancéreux, et des méthodes de traitement de la croissance cellulaire anormale en administrant ces associations à des patients.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)