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1. (WO2016055907) SYNERGISTIC AURISTATIN COMBINATIONS

Pub. No.:    WO/2016/055907    International Application No.:    PCT/IB2015/057457
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Wed Sep 30 01:59:59 CEST 2015
IPC: A61K 31/4015
A61K 31/4025
A61K 45/06
A61K 31/166
A61P 35/00
Applicants: PFIZER INC.
Inventors: SAPRA, Puja
SHOR, Boris
Title: SYNERGISTIC AURISTATIN COMBINATIONS
Abstract:
This invention relates to combinations of an auristatin or an auristatin-based antibody-drug-conjugate (ADC) with second active agents including PI3K/mTOR inhibitors, MEK inhibitors, taxanes, or other anti-cancer agents, and methods of treating abnormal cell growth by administering these combinations to patients.