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1. (WO2016055836) METHOD FOR PRODUCING AND USING THE RK39-KDDR PROTEIN AND LEISHMANIASIS DIAGNOSTIC KIT
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/055836    International Application No.:    PCT/IB2014/065188
Publication Date: 14.04.2016 International Filing Date: 09.10.2014
IPC:
C07K 14/44 (2006.01), A61K 39/008 (2006.01), C12N 15/30 (2006.01), G01N 33/569 (2006.01), A61P 33/02 (2006.01)
Applicants: UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG [BR/BR]; Avenida Antônio Carlos, 6627, Unidade Administrativa II, 2° andar, sala 2012. Pampuha. 31270-901 Belo Horizonte (BR).
FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE MINAS GERAIS- FAPEMIG [BR/BR]; Rua Raul Pompéia, 101, 11° andar, Bairro São Pedro 30330-080 Belo Horizonte (BR)
Inventors: FUJIWARA, Ricardo Toshio; (BR).
BARTHOLOMEU, Daniella Castanheira; (BR).
BUENO, Lilian Lacerda; (BR).
LEMOS, Lucas De Carvalho Dhom; (BR).
CUNHA, João Luis Reis; (BR).
MENDES, Tiago António De Oliveira; (BR)
Common
Representative:
UNIVERSIDADE FEDERAL DE MINAS GERAIS - UFMG; Avenida Antônio Carlos, 6627, Unidade Administrativa II, 2° andar, sala 2012. Pampuha. 31270-901 Belo Horizonte (BR)
Priority Data:
Title (EN) METHOD FOR PRODUCING AND USING THE RK39-KDDR PROTEIN AND LEISHMANIASIS DIAGNOSTIC KIT
(FR) PROCÉDÉ DE PRODUCTION ET D'UTILISATION DE LA PROTÉINE RK39-KDDR ET TROUSSE POUR LE DIAGNOSTIC DE LA LEISHMANIOSE
(PT) PROCESSO DE PRODUÇÃO E USO DA PROTEÍNA RK39-KDDR E KIT PARA DIAGNÓSTICO DE LEISHMANIOSE
Abstract: front page image
(EN)The present technology relates to a new heterologous expression process for the kinesin repeat, using specific primers which make it possible to construct a recombinant antigen with 7.5 repeats of K39 associated with a degenerated repeat, the KDDR (Kinesin Degenerated Derived Repeat). Also described is the use of this antigen (K39-KDDR) to diagnose leishmaniasis and as a vaccine, and a diagnostic kit containing this antigen.
(FR)La présente technologie décrit un nouveau procédé d'expression hétérologue de la partie répétitive de la kinésine, avec utilisation d'amorces spécifiques, permettant la construction d'un antigène recombinant avec 7,5 motifs répétitifs de la K39 associés à un motif répétitif dégénéré appelé KDDR (Kinesin Degenerated Derived Repeat). En outre, la technologie décrit l'utilisation de cet antigène (K39-KDDR) dans le diagnostic de la leishmaniose et comme vaccin, ainsi qu'une trousse de diagnostic contenant ledit antigène.
(PT)A presente tecnologia descreve um novo processo de expressão heteróloga da porção repetitiva da kinesina, com o uso de primers específicos, os quais permitiram a construção de um antígeno recombinante com 7.5 motivos repetitivos da K39 associados a um motivo repetitivo degenerado chamado de KDDR (Kinesin Degenerated Derived Repeat). Ainda, a tecnologia descreve o uso desse antígeno (K39-KDDR) no diagnóstico de leishmaniose e como vacina e um Kit diagnóstico contendo o mesmo antígeno.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: Portuguese (PT)
Filing Language: Portuguese (PT)