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1. (WO2016055454) PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF TUMORS

Pub. No.:    WO/2016/055454    International Application No.:    PCT/EP2015/073017
Publication Date: Fri Apr 15 01:59:59 CEST 2016 International Filing Date: Wed Oct 07 01:59:59 CEST 2015
IPC: A61K 31/282
A61K 31/337
A61K 31/395
A61K 31/404
A61K 31/4178
A61K 31/4725
A61K 31/506
A61K 31/513
A61K 31/65
A61P 35/00
Applicants: INTERNATIONAL SOCIETY FOR DRUG DEVELOPMENT S.R.L.
Inventors: RAPPOSELLI, Simona
MARTINI, Claudia
CALDERONE, Vincenzo
PURICELLI, Guido
Title: PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF TUMORS
Abstract:
The invention concerns a combination comprising at least one 2-oxo-indole derivative of formula (I) in which R1 is selected from the group consisting of thienyl, imidazolyl and pyridyl, optionally substituted by (C1-C3) alkyl, A is a -CH2CO- o -SO2- group; R is selected from the group consisting of 6,7-dimethoxy-1,2,3,4- tetrahydroisoquinolinyl, 3,4-dimethoxy-benzylamino, (C1-C3)alkyl, benzyl or a pharmaceutically acceptable salt thereof and at least one antitumor drug. The combination is for use in the treatment of tumors, in particular glioblastoma multiforme (GBM), breast tumor and pancreatic tumor. The combination is effective in the treatment of resistant tumor forms.