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1. (WO2016055394) SPIRODIAMINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/055394    International Application No.:    PCT/EP2015/072887
Publication Date: 14.04.2016 International Filing Date: 05.10.2015
IPC:
C07D 471/10 (2006.01), C07D 487/10 (2006.01), C07D 519/00 (2006.01), A61K 9/20 (2006.01), A61K 31/4725 (2006.01), A61K 31/4439 (2006.01), A61K 31/444 (2006.01), A61P 9/04 (2006.01), A61P 9/12 (2006.01), A61P 13/12 (2006.01), A61P 5/42 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel (CH) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
HOFFMANN-LA ROCHE INC. [US/US]; Great Notch, 150 Clove Road 8th Floor Little Falls, New Jersey 07424 (US) (US only)
Inventors: AEBI, Johannes; (CH).
AMREIN, Kurt E.; (CH).
CHEN, Junli; (CN).
HORNSPERGER, Benoit; (FR).
KUHN, Bernd; (CH).
LIU, Yongfu; (CN).
LI, Dongbo; (CN).
MAERKI, Hans Peter; (CH).
MARTIN, Rainer E.; (CH).
MAYWEG, Alexander; (CH).
TAN, Xuefei; (CN).
WU, Jun; (CN).
YU, Jianhua; (CN)
Agent: BERNARD, Guillaume; (CH)
Priority Data:
PCT/CN2014/088133 08.10.2014 CN
Title (EN) SPIRODIAMINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS
(FR) DÉRIVÉS D'ARYL-PYRIDINE EN TANT QU'INHIBITEURS D'ALDOSTÉRONE SYNTHASE
Abstract: front page image
(EN)The invention provides compounds having the general formula (I) pharmaceutical compositions containing the compounds and a process for their preparation. The compounds act as aldosterone synthase inhibitors and are for use in the treatment or prevention of chronic kidney disease, congestive heart failure, hypertension, primary aldosteronism and Cushing syndrom.
(FR)L'invention concerne des composés ayant la formule générale (I) des compositions pharmaceutiques contenant ces composés et un procédé pour leur préparation. Les composés agissent en tant qu'inhibiteurs de l'aldostérone synthase et sont destinés à être utilisés dans le traitement ou la prévention d'une maladie rénale chronique, l'insuffisance cardiaque congestive, l'hypertension, l'aldostéronisme primaire et du syndrome de Cushing.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)