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1. (WO2016054806) SUBSTITTUED PYRIDINE INHIBITORS OF HIF PROLYL HYDROXYLASE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/2016/054806 International Application No.: PCT/CN2014/088320
Publication Date: 14.04.2016 International Filing Date: 10.10.2014
IPC:
C07D 213/81 (2006.01) ,A61K 31/505 (2006.01) ,A61K 31/506 (2006.01) ,A61K 31/66 (2006.01) ,A61P 7/00 (2006.01)
Applicants: UJJAINWALLA, Fez[US/US]; US (US)
TAN, John Qiang[US/US]; US (US)
DANG, Qun[US/US]; US (US)
SINZ, Christopher J.[US/US]; US (US)
WANG, Ming[US/US]; US (US)
CHEN, Yili[US/US]; US (US)
CAI, Jiaqiang[GB/CN]; CN (US)
DU, Xiaoxing[CN/CN]; CN (US)
MERCK SHARP & DOHME CORP.[US/US]; 126 East Lincoln Avenue Rahway New Jersey 07065, US
Inventors: UJJAINWALLA, Fez; US
TAN, John Qiang; US
DANG, Qun; US
SINZ, Christopher J.; US
WANG, Ming; US
CHEN, Yili; US
CAI, Jiaqiang; CN
DU, Xiaoxing; CN
Agent: WU, FENG & ZHANG CO.; Room 305, Tower B, Beijing Aerospace Cpmiec Building No. 30, Haidian South Road, Haidian District, Beijing 100080, CN
Priority Data:
Title (EN) SUBSTITTUED PYRIDINE INHIBITORS OF HIF PROLYL HYDROXYLASE
(FR) PYRIDINES SUBSTITUÉES UTILISÉES COMME INHIBITEURS DE LA HIF PROLYL HYDROXYLASE
Abstract:
(EN) The present invention concerns compounds of formula I that inhibit HIF prolyl hydroxylase, their use for enhancing endogenous production of erythropoietin, and for treating conditions associated with reduced endogenous production of erythropoietin such as anemia and like conditions, as well as pharmaceutical compositions comprising such a compound and a pharmaceutical carrier.
(FR) La présente invention concerne des composés de formule I inhibant la HIF prolyl hydroxylase, leur utilisation pour augmenter la production endogène d'érythropoïétine et pour traiter des états associés à une production endogène réduite d'érythropoïétine, tels qu'une anémie et des états analogues, ainsi que des compositions pharmaceutiques contenant un tel composé et un vecteur de médicament.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)