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1. (WO2016054747) TREATMENT AND BIOMARKER FOR PULMONARY HYPOPLASIA IN CONGENITAL DIAPHRAGMATIC HERNIA
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/054747    International Application No.:    PCT/CA2015/051028
Publication Date: 14.04.2016 International Filing Date: 09.10.2015
IPC:
C12Q 1/68 (2006.01), G01N 33/48 (2006.01), C07H 21/00 (2006.01), C07H 21/02 (2006.01), C12N 15/113 (2010.01)
Applicants: UNIVERSITY OF MANITOBA [CA/CA]; Technology Transfer Office 631 Drake Bldg. 181 Freedman St Winnipeg, Manitoba R3T 5V4 (CA)
Inventors: KEIJZER, Richard; (CA)
Agent: ADE & COMPANY INC.; 2157 Henderson Highway Winnipeg, Manitoba R2G 1P9 (CA)
Priority Data:
62/062,459 10.10.2014 US
Title (EN) TREATMENT AND BIOMARKER FOR PULMONARY HYPOPLASIA IN CONGENITAL DIAPHRAGMATIC HERNIA
(FR) TRAITEMENT ET BIOMARQUEUR POUR L'HYPOPLASIE PULMONAIRE DANS L'HERNIE DIAPHRAGMATIQUE CONGÉNITALE
Abstract: front page image
(EN)Congenita! diaphragmatic hernia (CDH) is a developmental defect of the diaphragm, causing abdominal viscera to herniate into the thorax. A common genetic cause for CDH and the associated abnormal lung development has not been identified. We have found that human fetal hypoplastic CDH lungs have a specific microRNA miR-200/miR-10a signature, which changes in response to fetal therapy.
(FR)L'hernie diaphragmatique congénitale (HDC) est un défaut de développement du diaphragme, ce qui provoque l'hernie des viscères abdominaux dans le thorax. Une cause génétique commune pour la HDC et pour le développement pulmonaire anormal associé n'a pas été identifiée. Nous avons découvert que des poumons humains de HDC hypoplasiques foetaux présentent une signature micro-ARN miR-200/miR-10 spécifique, qui change en réponse à une thérapie foetale.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)