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1. (WO2016054504) ATROPINE SULFATE RAPIDLY-DISINTEGRATING SUBLINGUAL TABLETS, METHODS FOR MANUFACTURE, AND METHODS FOR USE THEREOF FOR TREATMENT OF ACUTE ORGANOPHOSPHATE TOXICITY

Pub. No.:    WO/2016/054504    International Application No.:    PCT/US2015/053713
Publication Date: Fri Apr 08 01:59:59 CEST 2016 International Filing Date: Sat Oct 03 01:59:59 CEST 2015
IPC: A61K 31/46
Applicants: NOVA SOUTHEASTERN UNIVERSITY
Inventors: RAWAS-QALAJI, Mutasem
AODAH, Alhussain
Title: ATROPINE SULFATE RAPIDLY-DISINTEGRATING SUBLINGUAL TABLETS, METHODS FOR MANUFACTURE, AND METHODS FOR USE THEREOF FOR TREATMENT OF ACUTE ORGANOPHOSPHATE TOXICITY
Abstract:
The invention provides atropine sulfate (AS) rapidly-disintegrating sublingual tablets (RDSTs) in a sublingual dosage form and methods for therapeutic use of the AS RDSTs for treatment of organophosphate (OP) exposure and acute toxicity. The AS RDSTs provide an alternative easy-to-use dosage form for the management of organophosphate toxicity. Additionally, the invention provides methods for formulation and quality evaluation of the atropine sulfate rapidly-disintegrating sublingual tablets.