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1. (WO2016054474) SELECTIVE PLANE ILLUMINATION MICROSCOPY (SPIM) SYSTEMS AND METHODS

Pub. No.:    WO/2016/054474    International Application No.:    PCT/US2015/053656
Publication Date: Fri Apr 08 01:59:59 CEST 2016 International Filing Date: Sat Oct 03 01:59:59 CEST 2015
IPC: G02B 21/16
Applicants: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventors: HUANG, Bo
MCGORTY, Ryan
Title: SELECTIVE PLANE ILLUMINATION MICROSCOPY (SPIM) SYSTEMS AND METHODS
Abstract:
In one embodiment, a selective plane illumination microscopy system for capturing light emitted by an illuminated specimen includes a specimen stage having a top surface adapted to support a specimen holder and an opening adapted to provide access to a bottom of the holder, and a selective plane illumination microscopy optical system positioned beneath the stage, the optical system including an excitation objective, a detection objective, and an open-top, hollow prism that is adapted to contain a liquid, wherein the prism is positioned within the opening of the stage and optical axes of the objectives are aligned with the prism such that the axes pass through the prism and intersect at a position near the top surface of the specimen stage.