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1. (WO2016054403) AFOBAZOLE NANOPARTICLES FORMULATION FOR ENHANCED THERAPEUTICS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/054403    International Application No.:    PCT/US2015/053537
Publication Date: 07.04.2016 International Filing Date: 01.10.2015
IPC:
A61K 9/51 (2006.01), A61K 9/54 (2006.01), A61K 31/5377 (2006.01)
Applicants: UNIVERSITY OF SOUTH FLORIDA [US/US]; 3802 Spectrum Blvd. Suite 100 Tampa, Florida 33612 (US) (AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BE, BF, BG, BH, BJ, BN, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CL, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GT, GW, HN, HR, HU, ID, IE, IL, IN, IR, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, ME, MG, MK, ML, MN, MR, MT, MW, MX, MY, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SI, SK, SL, SM, SN, ST, SV, SY, SZ, TD, TG, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only).
CUEVAS, Javier [US/US]; (US) (US only).
KATNIK, Christopher [US/US]; (US) (US only).
SUTARIYA, Vijaykumar B. [IN/US]; (US) (US only)
Inventors: CUEVAS, Javier; (US).
KATNIK, Christopher; (US).
SUTARIYA, Vijaykumar B.; (US)
Agent: LAWSON, Michele L.; (US)
Priority Data:
62/058,405 01.10.2014 US
62/067,718 23.10.2014 US
Title (EN) AFOBAZOLE NANOPARTICLES FORMULATION FOR ENHANCED THERAPEUTICS
(FR) FORMULATION DE NANOPARTICULES D’AFOBAZOLE POUR AGENTS THÉRAPEUTIQUES AMÉLIORÉS
Abstract: front page image
(EN)A novel nanoparticle drug composition and method of use thereof is presented herein. The nanoparticle drug composition is comprised of at least one nanoparticle carrier, formed from the conjugation of PLGA and PEG, which encapsulates a drug such as afobazole and its derivatives, in a pharmaceutically acceptable carrier. The nanoparticle drug composition may be used to treat various diseases of the central nervous system involving excessive neuronal activity and inflammation such as stroke, Alzheimer's disease and anxiety.
(FR)La présente invention concerne une nouvelle composition de médicament à base de nanoparticules et un procédé d'utilisation de celle-ci. La composition de médicament à base de nanoparticules est constituée d'au moins un support de nanoparticule, formé par la conjugaison de PLGA et PEG, qui encapsule un médicament tel que l'afobazole et ses dérivés, dans un support pharmaceutiquement acceptable. La composition de médicament à base de nanoparticules peut être utilisée pour traiter différentes maladies du système nerveux central impliquant une activité neuronale excessive et une inflammation telles qu'un accident vasculaire cérébral, la maladie d'Alzheimer et l'anxiété.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)