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1. (WO2016054218) METHODS OF TREATING SYSTEMIC LUPUS ERYTHEMATOSUS USING A DOMAIN ANTIBODY DIRECTED AGAINST CD28
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/054218    International Application No.:    PCT/US2015/053233
Publication Date: 07.04.2016 International Filing Date: 30.09.2015
IPC:
C07K 16/28 (2006.01), A61P 37/06 (2006.01)
Applicants: BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543 (US)
Inventors: VALENCIA, Xavier; (US).
THROUP, John P.; (US).
NADLER, Steven G.; (US).
SUCHARD, Suzanne J.; (US).
DUCHESNE, Dominique; (US).
LIU, Xiaoni; (US).
SHI, Rong; (US).
SHEVELL, Diane E.; (US).
XIE, Jenny H.; (US).
HONCZARENKO, Marek; (US)
Agent: GUO, Z. Angela; (US)
Priority Data:
62/057,981 30.09.2014 US
Title (EN) METHODS OF TREATING SYSTEMIC LUPUS ERYTHEMATOSUS USING A DOMAIN ANTIBODY DIRECTED AGAINST CD28
(FR) MÉTHODES DE TRAITEMENT DE LUPUS ÉRYTHÉMATEUX SYSTÉMIQUE À L'AIDE D'UN ANTICORPS À DOMAINE DIRIGÉ CONTRE CD28
Abstract: front page image
(EN)Methods of treating autoimmune diseases, such as systemic lupus erythematosus using domain antibodies that specifically bind human CD28 are provided. The methods may comprise at least one administration cycle comprising one dose of the domain antibody. The method reduces symptoms of systemic lupus erythematosus compared to placebo.
(FR)L'invention concerne également des méthodes de traitement de maladies auto-immunes, telles que le lupus érythémateux systémique à l'aide d'anticorps à domaine qui se lient spécifiquement au CD28 humain. Les méthodes peuvent comprendre au moins un cycle d'administration comprenant une dose de l'anticorps à domaine. La méthode réduit les symptômes du lupus érythémateux systémique comparé à un placébo.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)