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1. (WO2016054101) BISPECIFIC MOLECULES COMPRISING AN HIV-1 ENVELOPE TARGETING ARM

Pub. No.:    WO/2016/054101    International Application No.:    PCT/US2015/053027
Publication Date: Fri Apr 08 01:59:59 CEST 2016 International Filing Date: Wed Sep 30 01:59:59 CEST 2015
IPC: C07K 16/10
Applicants: DUKE UNIVERSITY
MACROGENICS, INC.
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Inventors: HAYNES, Barton, F.
FERRARI, Guido
KOENIG, Scott
JOHNSON, Leslie, S.
LAM, Chia-Ying, Kao
SUNG, Julia, A.
MARGOLIS, David, M.
LIU, Liqin
NORDSTROM, Jeffrey, Lee
Title: BISPECIFIC MOLECULES COMPRISING AN HIV-1 ENVELOPE TARGETING ARM
Abstract:
The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells wherein the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28 or CH44.