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1. (WO2016054101) BISPECIFIC MOLECULES COMPRISING AN HIV-1 ENVELOPE TARGETING ARM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2016/054101    International Application No.:    PCT/US2015/053027
Publication Date: 07.04.2016 International Filing Date: 29.09.2015
IPC:
C07K 16/10 (2006.01)
Applicants: DUKE UNIVERSITY [US/US]; 2812 Erwin Road Suite 306 Durham, NC 27705 (US).
MACROGENICS, INC. [US/US]; 9640 Medical Center Drive Rockville, MD 20850 (US).
UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 100 Europa Drive Suite 430 Chapel Hill, NC 27517 (US)
Inventors: HAYNES, Barton, F.; (US).
FERRARI, Guido; (US).
KOENIG, Scott; (US).
JOHNSON, Leslie, S.; (US).
LAM, Chia-Ying, Kao; (US).
SUNG, Julia, A.; (US).
MARGOLIS, David, M.; (US).
LIU, Liqin; (US).
NORDSTROM, Jeffrey, Lee; (US)
Agent: KIM, William, W.; (US)
Priority Data:
62/206,586 18.08.2015 US
62/056,834 29.09.2014 US
Title (EN) BISPECIFIC MOLECULES COMPRISING AN HIV-1 ENVELOPE TARGETING ARM
(FR) MOLÉCULES BISPÉCIFIQUES COMPRENANT UN BRAS DE CIBLAGE D'ENVELOPPE DU VIH-1
Abstract: front page image
(EN)The invention is directed to bispecific molecules comprising an HIV-1 envelope targeting arm and an arm targeting an effector cell, compositions comprising these bispecific molecules and methods of use. In certain aspects, the bispecific molecules of the present invention can bind to two different targets or epitopes on two different cells wherein the first epitope is expressed on a different cell type than the second epitope, such that the bispecific molecules can bring the two cells together. In certain aspects, the bispecific molecules of the present invention can bind to two different cells, wherein the bispecific molecules comprises an arm with the binding specificity of A32, 7B2, CH27, CH28 or CH44.
(FR)L'invention concerne des molécules bispécifiques comprenant un bras de ciblage d'enveloppe du VIH-1 et un bras ciblant une cellule effectrice, des compositions comprenant ces molécules bispécifiques et des procédés d'utilisation. Selon certains aspects, les molécules bispécifiques de la présente invention peuvent se lier à deux cibles ou épitopes différents sur deux cellules différentes, le premier épitope étant exprimé sur un type de cellule différent de celui du deuxième épitope, de telle sorte que les molécules bispécifiques peuvent rapprocher les deux cellules. Selon certains aspects, les molécules bispécifiques de la présente invention peuvent se lier à deux cellules différentes, les molécules bispécifiques comprenant un bras ayant la spécificité de liaison de A32, 7B2, CH27, CH28 ou CH44.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)